Περίληψη:
Objective A new derivative of 24 h ambulatory blood pressure monitoring
(ABPM) is introduced and its association with left ventricular mass
index (LVMI) in essential hypertension is examined.
Patient population One hundred and fifty-three previously untreated
essential hypertension patients.
Methods Patients underwent casual blood pressure (BP) readings, 24 h
ABPM and left ventricular echocardiographic assessment The following 24
h awake and sleep ABP variables were calculated: mean systolic and
diastolic BP, systolic and diastolic BP loads (percentage of systolic
readings > 140/120 mmHg (day/night) and diastolic readings > 90/80 mmHg
(day/night), standard deviation of systolic and diastolic ABP and
nocturnal fall of systolic BP, as well as the integrated areas under the
ABP curve. The area under the BP curve divided in horizontal slices was
accurately modelled by a sigmoid curve. The parameters controlling the
shape of the curve and in particular that regarding its ‘slope’ is
hereafter called the ‘pressure-time index’.
Results ‘Systolic pressure-time index 24 h’ (SPTI24) is related to left
ventricular mass index (multivariate analysis, P = 0.008). Using either
partial correlation coefficients or a multivariate analysis, SPTI24 is
related to left ventricular mass index, independently of age, casual
blood pressure, mean systolic and diastolic ABP, systolic and diastolic
BP loads, BP variability (standard deviation (SD), nocturnal fall of
systolic BP) and integrated area under the curve (multivariate analysis,
P = 0.004).
Conclusions In essential hypertension, the SPTI24 is related to LVMI
independently of age, casual blood pressure, integrated area under the
curve or any other derivative of 24 h ABPM, and might be used to assess
the extent of hypertensive load. J Hypertens 1999, 17:1387-1393 (C)
Lippincott Williams & Wilkins.
Συγγραφείς:
Zakopoulos, NA
Toumanidis, ST
Barlas, GJ
Nanas, SN and
Lekakis, JP
Stamatelopoulos, SF
Moulopoulos, SD
