Τίτλος:
HLA associations of anti-beta2 glycoprotein I response in a Greek cohort
with antiphospholipid syndrome and meta-analysis of four ethnic groups
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Using molecular typing, we evaluated the strength of class II HLA
associations in 67 Greek patients with antiphospholipid syndrome (APS),
54 of whom had antibodies against beta 2-glycoprotein I (beta 2GPI), as
compared to 246 controls. To further clarify and delineate HLA
associations of the beta 2GPI response, we combined these data with
individual patient data From three other ethnic groups including an
additional 74 patients with beta 2GPI response and 403 ethnically
matched controls of white, African-American, and Mexican-American origin
in a Formal meta-analysis. The major alleles associated with anti-beta
2GPI response are HLA-DQA1*03 (in particular *0301) and the
HLA-DRB1*1302-DQB1*0604 haplotype, while protection against
developing an anti-beta 2GPI response is related primarily to the
HLA-DRB1*0101-DQA1*0101 haplotype and the the HLA-DRB1*1101
allele. These effects are not significantly heterogeneous across ethnic
groups. The previously observed association with HLA-DQB1*0302 may
simply reflect linkage disequilibrium with HLA-DQA1*0301 and the
previously reported HLA-DQB1*06 effect is limited to
HLA-DQB1*0604/0605, while HLA-DQB1*0602 is unlikely to be important.
The metaanalysis clearly documents that the anti-beta 2GPI response is
determined by a few specific class II alleles and haplotypes. (C)
American Society for Histocompatibility and Immunogenetics, 1999.
Published by Elsevier Science Inc.
Συγγραφείς:
Ioannidis, JPA
Tektonidou, MG
Vlachoyiannopoulos, PG and
Stavropoulos-Giokas, C
Spyropoulou-Vlachou, M
Reveille, JD and
Arnett, FC
Moutsopoulos, HM
Περιοδικό:
Human Immunology
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Λέξεις-κλειδιά:
antiphospholipid syndrome; beta-2 glycoprotein I; class IIHLA alleles;
meta-analysis
DOI:
10.1016/S0198-8859(99)00122-6
