Περίληψη:
Galanin, a neuropeptide, is found in the central nervous system and in a
number of nonbrain areas including adrenal sympathetic medullar tissue
and pancreas. Several studies involve galanin in the regulation of GH,
which responds to stressful stimuli. This study refers to the
investigation of the effect of a 20-min exercise on plasma human galanin
(hGAL) and GH in middle-aged healthy volunteer adults. Thirteen
individuals, 5 males and 8 females aged 40-50 years (44.7 +/- 2.95) were
selected on the basis of normal body mass index (22.5 +/- 2.3 kg/m(2))
and the absence of endocrine or any other abnormality. Basal
concentrations of GH and hGAL were measured between 0800 and 0900h after
an overnight fast. Post exercise levels were recorded after termination
of the stressful test and 15 min thereafter. GH and hGAL were determined
by an immunoradiometric and radioimmunoassay, respectively. The
exercise-potentiated GH response in all subjects with post-exercise
levels significantly higher (11.09+/-1.8 ng/ml vs 1.27+/-0.7 ng/ml,
p<0.0001, F=32.44) with the peak in the hormone level detected 15 min
after the end of exercise (12.09+/-1.96 ng/ml). Plasma hGAL levels were
also substantially affected by the acute exercise test, in that post
exercise peripheral blood concentration was significantly higher from
the basal values (21.51+/-9.94 vs 13.46+/-7.2 pg/ml, p<0.02, F=5.50).
Again the hGAL values peaked 15 min after the end of exercise
(24.0+/-10.5 pg/ml, P<0.015, F = 4.68). However, the time-correlation of
the increments of GH and hGAL did not reach a statistically significant
level (20 min: r=0.41, p=0.161., 35 min: r=-0.095, P=0.758). These
results clearly show an independence of the two hormones. The
responsivity of hGAL of middle-aged individuals to the exercise stimulus
might be due to the higher releasable pool of the hormone.
Συγγραφείς:
Legakis, IN
Mantzouridis, T
Saramantis, A
Phenekos, C and
Tzioras, C
Mountokalakis, T
Εκδότης:
Marcel Dekker Inc, New York, NY, United States
