Περίληψη:
Background: It has been suggested that the dopaminergic system is
involved in the pathophysiology of mood disorders. We conducted a
multicenter study of families with mood disorders, to investigate a
possible linkage with genes coding for dopamine receptor D2, dopamine
receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood
disorder pedigrees collected within the framework of the European
Collaborative Project on Affective Disorders were analyzed with
parametric and non-parametric linkage methods. Various potential
phenotypes were considered, from a narrow (only bipolar as affected) to
a broad (bipolar + major depressive + schizoaffective disorders)
definition of affection status. Results: Parametric analyses excluded
linkage for all the candidate genes, even though small positive LOD
(Limit of Detection) scores were observed for TH in three families.
Non-parametric analyses yielded negative results for all markers.
Conclusion: The D2 and D3 dopamine receptors were, therefore, not a
major liability factor for mood disorders in our sample, whereas TH may
play a role in a subgroup of patients. (C) 2000 Elsevier Science B.V.
All rights reserved.
Συγγραφείς:
Serretti, A
Macciardi, F
Cusin, C
Lattuada, E
Souery, D
and Lipp, O
Mahieu, B
Van Broeckhoven, C
Blackwood, D and
Muir, W
Aschauer, HN
Heiden, AM
Ackenheil, M
Fuchshuber,
S
Raeymaekers, P
Verheyen, G
Kaneva, R
Jablensky, A and
Papadimitriou, GN
Dikeos, DG
Stefanis, CN
Smeraldi, E and
Mendlewicz, J
