Τίτλος:
Lifestyle factors and insulin-like growth factor 1 levels among elderly
men
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Insulin-like growth factor 1 (IGF-1) is a potentially important
determinant of disease; hence epidemiological identification of factors
that influence circulating IGF-1 is merited. We therefore analysed data
collected in Greece to determine the relationship between
anthropometric, lifestyle and dietary variables and serum levels of
ICF-1 among elderly men. We identified 51 men with prostate cancer, 50
men with benign prostatic hyperplasia, and 52 apparently healthy elderly
men (controls), all matched for age (+/-1 year). These 153 men provided
blood specimens and were interviewed using a validated lifestyle and
food frequency questionnaire. We performed multivariate linear
regression to identify potential predictors of circulating IGF-1. After
controlling for age, body mass index, smoking habits, alcohol drinking
and coffee consumption, each 5 cm increase in height predicted a 13.0%
increase in IGF-1 (95% CT 0.4-27.2%) among the controls and a 11.3%
increase in IGF-1 (95% CI 4.5-18.6%) among the entire study group.
None of the investigated dietary factors (total fat, carbohydrate,
protein, dairy products, tomatoes, calcium) were strongly related to
IGF-1 levels. The positive association between IGF-1 and height
integrates the empirical evidence linking IGF-1 and height with prostate
cancer risk. (C) 2000 Lippincott Williams & Wilkins.
Συγγραφείς:
Signorello, LB
Kuper, H
Lagiou, P
Wuu, J
Mucci, LA and
Trichopoulos, D
Adami, HO
Περιοδικό:
European Journal of Cancer Prevention: The Official Journal of the European Cancer Prevention Organisation (ECP)
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
dietary factors; height; insulin-like growth factor 1; prostate cancer
DOI:
10.1097/00008469-200006000-00004
