Περίληψη:
Background Angiotensin-converting enzyme (ACE) gene polymorphism has
been associated with an increased incidence of myocardial infarction.
Recent studies have investigated a potential influence of ACE gene
polymorphism on fibrinolysis or endothelial function. It has been
previously established that essential hypertension is accompanied by
endothelial dysfunction and fibrinolytic balance disorders. The aim of
our study was to study the relation between ACE gene polymorphism and
fibrinolytic/hemostatic factors as well as endothelial cell damage
markers in patients with hypertension.
Methods The following parameters were evaluated in 104 patients with
previously untreated hypertension: plasminogen activator inhibitor-1
(PAI-1), tissue plasminogen activator (IPA) antigen, fibrinogen,
D-dimer, and von Willebrand factor (vWF). The genotype of the ACE gene
was also determined (by the polymerase chain reaction method), and
patients were characterized according to the observed alleles as
deletion/deletion IDD), insertion/insertion till, or insertion/deletion
(ID).
Results Those with DD genotype tn = 42) had significantly higher plasma
levels of PAI-I antigen (P = .012), IPA antigen (P = .0001), fibrinogen
(P = .0002), D-dimer (P = .0001) and VWF (P = .0004) compared with ID (n
= 30) or II (n = 32) genotypes. The ACE gene genotypes appeared to be
significant predictors for plasma PAI-1 antigen, tPA antigen,
fibrinogen, D-dimer, and VWF even after adjustment for age, sex, body
mass index, triglyceride and cholesterol levels, and blood pressure.
Conclusions Our findings suggest that the ACE/DD genotype is associated
with hemostasis balance disturbances reflecting hypercoagulability and
endothelial damage in patients with untreated hypertension.
Συγγραφείς:
Makris, TK
Stavroulakis, GA
Dafni, UG
Gialeraki, AE and
Krespi, PG
Hatzizacharias, AN
Tsoukala, CG
Vythoulkas, JS
and Kyriakidis, MK
