Περίληψη:
Both E-and L-selectin are cell adhesion molecules. E-selectin is
expressed by activated endothelial cells, whereas L-selectin by
quiescent leukocytes and is rapidly cleaved off after activation. Both
selectins take part in the first step of the ‘adhesion cascade’, the
‘rolling of leukocytes’, leading to the extravasation of the white cells
to the sites of inflammation, infection or damage. For this reason their
soluble forms (sE- and sL-selectin, respectively),are considered early
and reliable markers of the immune activation and response. Moreover,
sE-selectin has been reported to be a potent angiogenic factor and a
reliable marker of infection and sepsis in neonates, as well as
endothelial activation, while sl-selectin of the leukocyte function and
maturity. Following informed maternal consent, we evaluated
prospectively by ELISA, sE- and sL-selectin in the serum of 40 (19
females, 21 males), healthy, term, infection-free neonates, on the
second and fifth day of life, and compared them with the respective
values in 20 healthy adults (10 females, 10 males), with the purpose of
examining the pattern of their values in the early postpartum days, and
to establish reference values for both selectins.Values (mean+/-S.D.) of
sE-selectin both on the second (139+/-48 ng/ml) and fifth day of life
(111+/-35 ng/ml) were found to be highly increased, as compared with
those in controls (48+/-13 ng/ml; P<4x 10(-11) and P<4x10-10,
respectively), while sL-selectin values on both the second (674+/-223
ng/ml) and the fifth day of life (684+/-1221 ng/ml), were significantly
lower than those in controls (938+/-181 ng/ml); P<0.0001 and P<0.0003,
respectively). A significant decrease was noted in sE-selectin values,
from the second to the fifth day of life (P < 10(-7)), while sL-selectin
values showed no significant change in the same time interval. A strong
correlation was found between values on the second and the fifth day of
life of both sE- and sL-selectin (r(p)=0.885 and r(p)=0.813,
respectively; P<0.00001). Neonatal values of both sE- and sl-selectin on
the second or on the fifth day of life, did not depend on the perinatal
factors, neonatal sex, or birth weight, mode of delivery, and maternal
age or parity. In conclusion, in the very early neonatal period, our
findings of highly increased sE-selectin, while low sl-selectin, suggest
an immune and more specifically endothelial activation and an immature
and decreased leukocyte function. (C) 2000 Elsevier Science Ireland Ltd.
All rights reserved.
Συγγραφείς:
Giannaki, G
Rizos, D
Xyni, K
Sarandakou, A and
Protonotariou, E
Phocas, I
Creatsas, G
