Περίληψη:
Multiple myeloma (MM) is rare among patients with sickle cell syndromes
(SCS). We describe six Greek sickle cell patients aged 56 to 65 years:
five haemoglobin S beta (+)thalassaemia (HbS beta (+)thal), one sickle
cell anaemia (HbSS), who developed MM (three IgGK, one IgG lambda, one
IgAK, and one IgGK-IgAK (biclonal). Our HbS beta (+)thal cases,
represent the first reported association of this entity with MM.
Generalized bleeding diathesis, stroke, grand mal seizures, bone marrow
necrosis and other clinical manifestations due to hyperviscosity
aggravated by sickle cell vasoocclusion were treated by plasmaphereses
and exchange blood transfusions. The increase of mean survival in SCS
patients due to the current medical facilities may have an impact on the
incidence of MM among them, if a pathogenetic link between the two
conditions exists. All our patients carried a diagnosis of
cholelithiasis which may predispose to MM; two of them progressed from a
monoclonal gammopathy of undetermined significance (MGUS) to MM. Further
studies are needed in order to understand the relationship between SCS
and MM.
Συγγραφείς:
Kaloterakis, A
Filiotou, A
Konstantopoulos, K
Rombos, Y and
Bossinakou, I
Hadziyannis, S
