Τίτλος:
Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Fibrotic diseases cover a spectrum of systemic and organ-specific maladies that affect a large portion of the population, currently without cure. The shared characteristic these diseases feature is their uncontrollable fibrogenesis deemed responsible for the accumulated damage in the susceptible tissues. Idiopathic Pulmonary Fibrosis, an interstitial lung disease, is one of the most common and studied fibrotic diseases and still remains an active research target. In this study we highlight unique and common (i) genes, (ii) biological pathways and (iii) candidate repurposed drugs among 9 fibrotic diseases. We identify 7 biological pathways involved in all 9 fibrotic diseases as well as pathways unique to some of these diseases. Based on our Drug Repurposing results, we suggest captopril and ibuprofen that both appear to slow the progression of fibrotic diseases according to existing bibliography. We also recommend nafcillin and memantine, which haven't been studied against fibrosis yet, for further wet-lab experimentation. We also observe a group of cardiomyopathy-related pathways that are exclusively highlighted for Oral Submucous Fibrosis. We suggest digoxin to be tested against Oral Submucous Fibrosis, since we observe cardiomyopathy-related pathways implicated in Oral Submucous Fibrosis and there is bibliographic evidence that digoxin may potentially clear myocardial fibrosis. Finally, we establish that Idiopathic Pulmonary Fibrosis shares several involved genes, biological pathways and candidate inhibitingdrugs with Dupuytren's Disease, IgG4-related Disease, Systemic Sclerosis and Cystic Fibrosis. We propose that treatments for these fibrotic diseases should be jointly pursued. © 2021 Karatzas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Συγγραφείς:
Karatzas, E.
Kakouri, A.C.
Kolios, G.
Delis, A.
Spyrou, G.M.
Εκδότης:
Public Library of Science
Αριθμός / τεύχος:
4 April
Λέξεις-κλειδιά:
antifibrotic agent; captopril; cystic fibrosis transmembrane conductance regulator; digoxin; ibuprofen; memantine; nafcillin; drug; transcriptome, Article; controlled study; cystic fibrosis; drug mechanism; Dupuytren contracture; fibrogenesis; fibrosing alveolitis; gene expression profiling; heart muscle fibrosis; human; immunoglobulin G4 related disease; interstitial lung disease; mouth disease; systemic sclerosis; drug repositioning; fibrosing alveolitis; fibrosis; genetics; interstitial lung disease; procedures; signal transduction, Drug Repositioning; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pharmaceutical Preparations; Signal Transduction; Transcriptome
DOI:
10.1371/journal.pone.0249687
