Τίτλος:
Pre-operative intravitreal dexamethasone implant in patients with refractory diabetic macular edema undergoing cataract surgery
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
To examine preoperative use of intravitreal dexamethasone implant in patients with refractory diabetic macular edema (DME) undergoing cataract surgery. Participants in this study were 17 patients with DME refractory to previous treatment with anti-vascular endothelial growth factor agents or dexamethasone implant, and co-existent cataract. All participants received intravitreal dexamethasone implant at baseline and underwent phacoemulsification within one month after its insertion. Best-corrected visual acuity (BCVA) and central subfield thickness (CST) changes between baseline, time of cataract surgery and postoperative months 1, 2 and 3 were evaluated. At month 1 after surgery, BCVA improved significantly from 42.3 ± 9.6 to 58.7 ± 11.9 letters compared to baseline (p < 0.001) and the improvement was sustained at month 2 and month 3 postoperatively. One month postoperatively, CST improved significantly compared to baseline (p < 0.001) and the improvement was sustained at month 2 (p < 0.001), while at month 3 CST started to increase, but remained significantly lower than baseline (p = 0.003). At month 3 postoperatively, 35.3% of patients presented recurrence of ME. Patients with refractory DME and cataract can safely undergo phacoemulsification when dexamethasone implant is inserted one month prior to surgery to ensure adequate control of postoperative inflammation and prevent deterioration of ME. © 2020, The Author(s).
Συγγραφείς:
Kabanarou, S.A.
Xirou, T.
Boutouri, E.
Gkizis, I.
Vasilias, D.
Bontzos, G.
Chatziralli, I.
Περιοδικό:
Scientific Reports
Εκδότης:
Institute of Geographic Sciences and Natural Resources Research
Λέξεις-κλειδιά:
dexamethasone, aged; biodegradable implant; cataract extraction; delayed release formulation; diabetic retinopathy; female; human; intravitreal drug administration; macular edema; male; phacoemulsification; preoperative care; procedures; treatment outcome; very elderly; visual acuity, Absorbable Implants; Aged; Aged, 80 and over; Cataract Extraction; Delayed-Action Preparations; Dexamethasone; Diabetic Retinopathy; Female; Humans; Intravitreal Injections; Macular Edema; Male; Phacoemulsification; Preoperative Care; Treatment Outcome; Visual Acuity
DOI:
10.1038/s41598-020-62561-3
