Τίτλος:
The effectiveness of a community-based, type 2 diabetes prevention programme on healthrelated quality of life. The DE-PLAN study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and aims The DE-PLAN was a European multicenter study, with the primary objective of testing whether a community-based lifestyle modification programme could serve as a means of primary prevention for type 2 diabetes (T2D) in high-risk individuals (based on the FINDRISC questionnaire). The aim of this study was to examine the impact of a 1-year community- based lifestyle intervention on health-related quality of life (HRQOL) in individuals from four participating European centers (Athens, Barcelona, Krakow, Kaunas), through a posthoc analysis. Materials and methods Each center was allowed to implement different intervention strategies specifically tailored to the needs of their corresponding population sample. Before and after the intervention, participants underwent clinical evaluation, anthropometric measurements, an oral glucose tolerance test and lipid profile measurements. Health-related quality of life was assessed using the validated HRQOL-15D questionnaire. A difference of ±0.015 in the 15D questionnaire score was set as the threshold of clinically meaningful change. Results Data from 786 participants (67% females, mean age 59.7±9.4 years, BMI 31.5±4.5 kg/m2) with complete data regarding the HRQOL were analyzed (Athens: 104, Barcelona: 434, Krakow: 175, Kaunas: 70). After 1 year, a significant overall improvement in HRQOL was shown, as depicted by a change of 15D score from baseline value (0.88±0.9) to post-intervention (0.90±0.87, P<0.001), achieving the threshold of clinically meaningful change. A significant weight reduction was also observed (-0.8±4.0 kg, P<0.001). In multivariate analysis, improvement in HRQOL was independently associated with lower 15D score at baseline (P<0.001) and self-reported increase in overall exercise time (P<0.001) as assessed through specifically designed trial questionnaires. Conclusion A community-based lifestyle intervention programme aiming at T2D prevention, applied on a heterogeneous population and with varied methods, was shown to improve overall healthrelated quality of life to a clinically meaningful degree. © 2019 Karamanakos et al. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Karamanakos, G.
Costa-Pinel, B.
Gilis-Januszewska, A.
Velickiene, D.
Barrio-Torrell, F.
Cos-Claramunt, X.
Mestre-Miravet, S.
Piwoñska-Solska, B.
Hubalewska-Dydejczyk, A.
Tuomilehto, J.
Liatis, S.
Makrilakis, K.
Εκδότης:
Public Library of Science
Λέξεις-κλειδιά:
adult; anthropometric parameters; Article; body weight loss; clinical evaluation; community care; controlled study; Europe; exercise; female; Greece; high risk patient; human; lifestyle modification; lipid fingerprinting; Lithuania; major clinical study; male; non insulin dependent diabetes mellitus; oral glucose tolerance test; Poland; post hoc analysis; primary prevention; program effectiveness; quality of life; self report; Spain; aged; clinical trial; middle aged; multicenter study; non insulin dependent diabetes mellitus; public health; questionnaire; risk reduction, Aged; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Public Health; Quality of Life; Risk Reduction Behavior; Surveys and Questionnaires
DOI:
10.1371/journal.pone.0221467
