Analysis of shared heritability in common disorders of the brain

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3056588 93 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Analysis of shared heritability in common disorders of the brain
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology. © 2018 American Association for the Advancement of Science. All rights reserved.
Έτος δημοσίευσης:
2018
Συγγραφείς:
Anttila, V.
Bulik-Sullivan, B.
Finucane, H.K.
Walters, R.K.
Bras, J.
Duncan, L.
Escott-Price, V.
Falcone, G.J.
Gormley, P.
Malik, R.
Patsopoulos, N.A.
Ripke, S.
Wei, Z.
Yu, D.
Lee, P.H.
Turley, P.
Grenier-Boley, B.
Chouraki, V.
Kamatani, Y.
Berr, C.
Letenneur, L.
Hannequin, D.
Amouyel, P.
Boland, A.
Deleuze, J.-F.
Duron, E.
Vardarajan, B.N.
Reitz, C.
Goate, A.M.
Huentelman, M.J.
Ilyas Kamboh, M.
Larson, E.B.
Rogaeva, E.
George-Hyslop, P.S.
Hakonarson, H.
Kukull, W.A.
Farrer, L.A.
Barnes, L.L.
Beach, T.G.
Yesim Demirci, F.
Head, E.
Hulette, C.M.
Jicha, G.A.
Kauwe, J.S.K.
Kaye, J.A.
Leverenz, J.B.
Levey, A.I.
Lieberman, A.P.
Pankratz, V.S.
Poon, W.W.
Quinn, J.F.
Saykin, A.J.
Schneider, L.S.
Smith, A.G.
Sonnen, J.A.
Stern, R.A.
Van Deerlin, V.M.
Van Eldik, L.J.
Harold, D.
Russo, G.
Rubinsztein, D.C.
Bayer, A.
Tsolaki, M.
Proitsi, P.
Fox, N.C.
Hampel, H.
Owen, M.J.
Mead, S.
Passmore, P.
Morgan, K.
Nöthen, M.M.
Rossor, M.
Lupton, M.K.
Hoffmann, P.
Kornhuber, J.
Lawlor, B.
McQuillin, A.
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Ruiz, A.
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Ransmayr, G.
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Cruchaga, C.
Alegret, M.
Winsvold, B.
Palta, P.
Farh, K.-H.
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Guerreiro, R.
Holmans, P.
Kendler, K.S.
Koeleman, B.
Mathews, C.A.
Price, A.
Scharf, J.
Sklar, P.
Williams, J.
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Smoller, J.W.
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Neale, B.M.
The Brainstorm Consortium
Περιοδικό:
SCIENCE CHINA Information Sciences
Εκδότης:
American Association for the Advancement of Science
Τόμος:
360
Αριθμός / τεύχος:
6395
Λέξεις-κλειδιά:
brain; disability; epidemiology; genetic analysis; genome; heritability; nervous system disorder; risk factor; symptom, Alzheimer disease; anorexia nervosa; Article; attention deficit disorder; bipolar disorder; brain ischemia; cognition; comorbidity; controlled study; educational status; genetic association; genetic risk; genetic variability; genome-wide association study; Gilles de la Tourette syndrome; heritability; human; major depression; mental disease; migraine; neurologic disease; neurosis; onset age; phenotype; priority journal; schizophrenia; brain disease; classification; genetic variation; genetics; mental disease; quantitative trait; risk factor, Brain Diseases; Genetic Variation; Genome-Wide Association Study; Humans; Mental Disorders; Phenotype; Quantitative Trait, Heritable; Risk Factors
Επίσημο URL (Εκδότης):
DOI:
10.1126/science.aap8757
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