Τίτλος:
Linking pre-diabetes with benign prostate hyperplasia. IGFBP-3: A conductor of benign prostate hyperplasia development orchestra?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Benign prostatic hyperplasia (BPH) represents a pattern of non-malignant growth of prostatic fibromuscular stroma. Metabolic disturbances such us pre-diabetes and metabolic syndrome may have a role in BPH pathophysiology. A potential explanation for the above relationship involves the insulin-like growth factor (IGF) axis as well as IGF binding proteins, (IGFBPs) of which the most abundant form is IGFBP-3. Therefore, the aim of the present study was to investigate the association between intra-prostatic levels of IGF-1, IGF-2 as well as to evaluate the role of locally expressed IGFBP-3 in BPH development in pre-diabetes. A total of 49 patients admitted to the Urology department of a tertiary urban Greek hospital, for transurethral prostate resection, or prostatectomy and with pre-diabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) or both] were finally included. The majority of the sample consisted of subjects with IGT (51.0%), followed by IFG and IGT (32.7%) and isolated IFG (16.3%). For all participants a clinical examination was performed and blood samples were collected. In addition, total prostate (TP) volume or transitional zone (TZ) volume were estimated by transrectal ultrasonography. The results of the multivariate analysis regarding TP volume showed that higher PSA (p<0.001), larger waist circumference (p=0.007) and higher IGFBP-3 expression levels (p<0.001) independently predicted higher TP volume. The results regarding the volume of the TZ showed that higher PSA (p<0.001), larger waist circumference (p<0.001) and higher IGFBP-3 expression levels (p=0.024) were independently associated with higher TZ volume. Our findings show that intraprostatic levels of IGFBP-3, PSA and waist circumference, but not overall obesity, are positively associated with prostate volume. IGFBP-3 seems to be a multifunctional protein, which can potentiate or inhibit IGF activity. © 2013 Protopsaltis et al.
Συγγραφείς:
Protopsaltis, I.
Ploumidis, A.
Sergentanis, T.N.
Constantoulakis, P.
Tzirogiannis, K.
Kyprianidou, C.
Papazafiropoulou, A.K.
Melidonis, A.
Delakas, D.
Λέξεις-κλειδιά:
prostate specific antigen; somatomedin B; somatomedin binding protein 3; somatomedin C, adult; aged; article; blood sampling; clinical article; clinical examination; controlled study; disease association; disorders of carbohydrate metabolism; Greece; human; human tissue; impaired fasting glucose; impaired glucose tolerance; male; male genital tract parameters; obesity; pathophysiology; prostate hypertrophy; prostate volume; prostatectomy; protein analysis; protein expression; protein function; tissue level; transitional zone volume; transrectal ultrasonography; transurethral resection; waist circumference, Aged; Aged, 80 and over; Humans; Insulin-Like Growth Factor Binding Protein 3; Male; Middle Aged; Multivariate Analysis; Prediabetic State; Prostatic Hyperplasia; Real-Time Polymerase Chain Reaction; Waist Circumference
DOI:
10.1371/journal.pone.0081411
