Τίτλος:
Comparison of associations between mortality and air pollution exposure estimated with a hybrid, a land-use regression and a dispersion model
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: To characterize air pollution exposure at a fine spatial scale, different exposure assessment methods have been applied. Comparison of associations with health from different exposure methods are scarce. The aim of this study was to evaluate associations of air pollution based on hybrid, land-use regression (LUR) and dispersion models with natural cause and cause-specific mortality. Methods: We followed a Dutch national cohort of approximately 10.5 million adults aged 29+ years from 2008 until 2012. We used Cox proportional hazard models with age as underlying time scale and adjusted for several potential individual and area-level socio-economic status confounders to evaluate associations of annual average residential NO2, PM2.5 and BC exposure estimates based on two stochastic models (Dutch LUR, European-wide hybrid) and deterministic Dutch dispersion models. Results: Spatial variability of PM2.5 and BC exposure was smaller for LUR compared to hybrid and dispersion models. NO2 exposure variability was similar for the three methods. Pearson correlations between hybrid, LUR and dispersion modeled NO2 and BC ranged from 0.72 to 0.83; correlations for PM2.5 were slightly lower (0.61–0.72). In general, all three models showed stronger associations of air pollutants with respiratory disease and lung cancer mortality than with natural cause and cardiovascular disease mortality. The strength of the associations differed between the three exposure models. Associations of air pollutants estimated by LUR were generally weaker compared to associations of air pollutants estimated by hybrid and dispersion models. For natural cause mortality, we found a hazard ratio (HR) of 1.030 (95% confidence interval (CI): 1.019, 1.041) per 10 µg/m3 for hybrid modeled NO2, a HR of 1.003 (95% CI: 0.993, 1.013) per 10 µg/m3 for LUR modeled NO2 and a HR of 1.015 (95% CI: 1.005, 1.024) per 10 µg/m3 for dispersion modeled NO2. Conclusion: Air pollution was positively associated with natural cause and cause-specific mortality, but the strength of the associations differed between the three exposure models. Our study documents that the selected exposure model may contribute to heterogeneity in effect estimates of associations between air pollution and health. © 2020 The Authors
Συγγραφείς:
Klompmaker, J.O.
Janssen, N.
Andersen, Z.J.
Atkinson, R.
Bauwelinck, M.
Chen, J.
de Hoogh, K.
Houthuijs, D.
Katsouyanni, K.
Marra, M.
Oftedal, B.
Rodopoulou, S.
Samoli, E.
Stafoggia, M.
Strak, M.
Swart, W.
Wesseling, J.
Vienneau, D.
Brunekreef, B.
Hoek, G.
Περιοδικό:
Environment International
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
Atmospheric movements; Diseases; Economics; Hazards; Land use; Nitrogen oxides; Stochastic models; Stochastic systems, Air pollution exposures; Cardio-vascular disease; Confidence interval; Cox proportional hazard model; Dispersion modeling; Land use regression; Lung cancer mortality; Socio-economic status, Air pollution, nitrogen dioxide; nitrogen dioxide, atmospheric modeling; atmospheric pollution; comparative study; dispersion; land use change; mortality; nitrogen dioxide; particulate matter; pollution exposure, adult; age; air pollutant; air pollution; Article; cancer mortality; cardiovascular disease; cardiovascular mortality; cause of death; cerebrovascular disease; chronic obstructive lung disease; cohort analysis; controlled study; deterministic dispersion model; Dutchman; european wide hybrid model; female; human; intermethod comparison; ischemic heart disease; land use regression model; lung cancer; major clinical study; male; middle aged; mortality; PM2.5 exposure; priority journal; respiratory tract disease; stochastic model; adverse event; air pollutant; analysis; environmental exposure; particulate matter; respiratory tract disease; toxicity, Netherlands, Adult; Air Pollutants; Air Pollution; Cohort Studies; Environmental Exposure; Humans; Nitrogen Dioxide; Particulate Matter; Respiratory Tract Diseases
DOI:
10.1016/j.envint.2020.106306
