Περίληψη:
Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epi-demiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe ac-counted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions. © 2020 by the authors. Li-censee MDPI, Basel, Switzerland.
Συγγραφείς:
Medina, N.
Soto-Debrán, J.C.
Seidel, D.
Akyar, I.
Badali, H.
Barac, A.
Bretagne, S.
Cag, Y.
Cassagne, C.
Castro, C.
Chakrabarti, A.
Dannaoui, E.
Cardozo, C.
Garcia-Rodriguez, J.
Guitard, J.
Hamal, P.
Hoenigl, M.
Jagielski, T.
Khodavaisy, S.
Lo Cascio, G.
Martínez-Rubio, M.C.
Meletiadis, J.
Muñoz, P.
Ochman, E.
Peláez, T.
Balzola, A.P.-A.
Prattes, J.
Roilides, E.
de Pipaón, M.R.-P.
Stauf, R.
Steinmann, J.
Suárez-Barrenechea, A.I.
Tejero, R.
Trovato, L.
Viñuela, L.
Wongsuk, T.
Żak, I.
Zarrinfar, H.
Lass-Flörl, C.
Arikan-Akdagli, S.
Alastruey-Izquierdo, A.
