Τίτλος:
Phytochemical analysis and biological evaluation of selected african propolis samples from Cameroon and congo
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The objective of this study was the chemical analysis of four selected samples of African propolis (Congo and Cameroon) and their biological evaluation. Twenty-one secondary metabolites belonging to four different chemical groups were isolated from the 70% ethanolic extracts of propolis and their structures were elucidated on the basis of spectral evidence. Three triterpenes and two diprenyl-flavonoids were identified from Congo propolis, which has been investigated for the first time, while thirteen triterpenes, three diprenyl-flavonoids, two monoterpenic alcohols and one fatty acid ester have been identified from Cameroon propolis samples. To our knowledge, the identified diprenyl-flavonoids, as well as five of the isolated and determined triterpenes, are reported for the first time in propolis. Moreover, the total polyphenol content was estimated in all extracts and the antimicrobial activities of all four extracts were studied against six Gram-positive and-negative bacteria and three pathogenic fungi, showing an interesting antibacterial profile.
Συγγραφείς:
Papachroni, D.
Graikou, K.
Kosalec, I.
Damianakos, H.
Ingram, V.
Chinou, I.
Περιοδικό:
Natural Product Communications
Εκδότης:
Natural Product Incorporation
Λέξεις-κλειδιά:
6,8 diprenyl aromadendrin; alcohol; alpha amyrin; alpha amyrone; amoxicillin; amphotericin; baccharen 12,21 dien 3beta ol; beta acetoxy amyrin; beta amyrin; betulin aldehyde; clavulanic acid; erythrodiol; flavonoid; flucytosine; lespedezaflavanone C; lonchocarpol A; netilmicin; propolis; triterpene derivative; unclassified drug; plant medicinal product; propolis, antimicrobial activity; Article; Cameroon; Candida albicans; Candida glabrata; Candida tropicalis; Congo; controlled study; drug identification; drug isolation; drug structure; Escherichia coli; Klebsiella pneumoniae; minimum inhibitory concentration; nonhuman; phytochemistry; Pseudomonas aeruginosa; Staphylococcus aureus; Staphylococcus epidermidis; chemistry; comparative study; microbial sensitivity test, Cameroon; Congo; Microbial Sensitivity Tests; Phytochemicals; Propolis
DOI:
10.1177/1934578x1501000118
