Τίτλος:
Effects of terpenoids from Salvia willeana in delayed-type hypersensitivity, human lymphocyte proliferation and cytokine production
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The effect of the lipophilic extract of S. willeana and three terpenoids isolated therefrom, camphor, lupeol and oleanolic acid, on oxazolone-induced hypersensitivity was evaluated. The extract reduced the ear edema by 46% at 24 h after challenge. All three terpenoids inhibited the edema and suppressed cytokines release at different rates. Lupeol inhibited the swelling by over 50% and reduced the production of IL-1β by 62%. Camphor caused inhibition of the efferent phase (45% inhibition at 72 h) and the levels of IL-1β, IL-4 and TNF-α (around 80% inhibition). Oleanolic acid diminished moderately the reaction and the levels of IL-4 and TNF-α. We also demonstrated that the three terpenoids inhibited human T-lymphocytes proliferation in a concentration-dependent manner and induced their apoptosis. Thus, these terpenoids could be considered anti-inflammatory constituents of S. willeana.
Συγγραφείς:
Vonaparti, A.
Karioti, A.
Recio, M.C.
Máñez, S.
Ríos, J.L.
Skaltsa, E.
Giner, R.M.
Περιοδικό:
Natural Product Communications
Εκδότης:
Natural Product Incorporation
Λέξεις-κλειδιά:
camphor; interleukin 1beta; interleukin 4; lupeol; nitric oxide; oleanolic acid; plant extract; Salvia willeana extract; tumor necrosis factor alpha; unclassified drug, animal experiment; antiinflammatory activity; apoptosis; article; cell cycle; cell viability; concentration response; controlled study; cytokine production; cytokine release; cytotoxicity; delayed hypersensitivity; ear; edema; enzyme linked immunosorbent assay; female; human; human cell; IC 50; lymphocyte proliferation; macrophage; mitochondrion; mouse; nonhuman; Salvia; Salvia willeana, Dryobalanops; Salvia
DOI:
10.1177/1934578x0800301202
