Τίτλος:
New alkylresorcinols from a lipophilic extract of Urginea indica L. bulbs showing experimental trauma healing activity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Several alkylresorcinols presenting the substitution pattern of structures I (3-methyl ether of 5-alkyl-2-methylresorcinol) and II (1,3-dimethyl ether of 5-alkylresorcinol), were isolated from the dichloromethane extract of the air-dried bulbs of Urginea indica L. Compounds of structure I with 15, 17 and 20 carbon atoms in the alkyl chain as well as compounds of structure II with 20, 22, 24 carbon atoms in the alkyl chain are new. The structures of the new compounds were elucidated on the basis of their NMR and MS data. The exact number of homologues in each series I and II and the exact length of the side chain were found using GC-MS analysis. The dichloromethane extract of the bulbs was evaluated for its trauma healing properties after local application and a statistically significant tendency to trauma remodeling was observed in comparison to control groups. © 2014 Elsevier B.V. All rights reserved.
Συγγραφείς:
Mikail, H.G.
Karvouni, H.
Kotsiou, A.
Tesseromatis, C.
Magiatis, P.
Λέξεις-κλειδιά:
cichoriol a; plant extract; resorcinol derivative; unclassified drug; Urginea indica extract; urgineol a; urgineol a f; urgineol b; urgineol c; urgineol d; urgineol e; wound healing promoting agent; resorcinol derivative; squill, animal experiment; animal model; Article; carbon nuclear magnetic resonance; chemotaxonomy; column chromatography; controlled study; drug isolation; drug structure; Liliaceae; male; mass fragmentography; nonhuman; plant bulb; priority journal; proton nuclear magnetic resonance; rat; skin injury; thin layer chromatography; Urginea indica; wound healing; animal; chemical structure; chemistry; drug effects; isolation and purification; plant root; skin; Wistar rat; wound healing, Urginea, Animals; Male; Molecular Structure; Plant Roots; Rats, Wistar; Resorcinols; Skin; Urginea; Wound Healing
DOI:
10.1016/j.fitote.2014.12.008
