Τίτλος:
The effects of nitroglycerin during cardiopulmonary resuscitation
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may decrease endocardial and cerebral organ blood flow. Nitroglycerin has a favourable haemodynamic profile which promotes forward blood flow. Several studies suggest that combined use of nitroglycerin with vasopressors during resuscitation, is associated with increased rates of resuscitation and improved post-resuscitation outcome. This article reviews the effects of nitroglycerin during cardiopulmonary resuscitation and postresuscitation period, as well as the beneficial outcomes of a combination regimen consisting of a vasopressor and a vasodilator, such as nitroglycerin. © 2014 Elsevier B.V. All rights reserved.
Συγγραφείς:
Stefaniotou, A.
Varvarousi, G.
Varvarousis, D.P.
Xanthos, T.
Περιοδικό:
European Journal of Pharmacology
Λέξεις-κλειδιά:
adrenalin; glyceryl trinitrate; vasopressin; glyceryl trinitrate; neuroprotective agent; vasoconstrictor agent, coronary artery blood flow; dose response; drug effect; drug efficacy; drug megadose; drug potency; heart arrest; heart protection; human; low drug dose; microvasculature; neuroprotection; neurotoxicity; nonhuman; pathophysiology; priority journal; reperfusion injury; resuscitation; review; survival rate; treatment outcome; animal; procedures; reperfusion injury; resuscitation, Animals; Cardiopulmonary Resuscitation; Humans; Neuroprotective Agents; Nitroglycerin; Reperfusion Injury; Vasoconstrictor Agents
DOI:
10.1016/j.ejphar.2014.04.002
