Τίτλος:
In vivo investigation of the efficiency of a nanoparticle-emulsion containing polihexanide on the human skin
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Skin antisepsis is a key element for the prevention of surgical site infections, as well as for infections after injection and punctures. Recent investigations have shown that about 25% of the resident bacterial flora of the human skin resides within the hair follicle. These findings strongly suggest that the skin appendages play the role of a bacterial reservoir. The bacteria within the hair follicles therefore may be the cause of endogenous germ repopulation after skin antisepsis, highlighting the need for new antiseptic formulations that can sufficiently penetrate into the hair follicles. Various experiments have found that nano-sized particles as well as oil-in-water emulsions are efficient carriers for substances into the hair follicles. In the present study, we investigated the in vivo antiseptic potential of the particle-associated and aqueous polihexanide on the human skin by monitoring bacterial growth after antisepsis over a period of 2.5 h. The experiments suggest that the use of a particle-bound antiseptic can achieve a better and longer lasting antisepsis of the human skin than in non-particulate form. © 2013 Elsevier B.V. All rights reserved.
Συγγραφείς:
Ulmer, M.
Patzelt, A.
Vergou, T.
Richter, H.
Müller, G.
Kramer, A.
Sterry, W.
Czaika, V.
Lademann, J.
Περιοδικό:
European Journal of Pharmaceutics and Biopharmaceutics
Λέξεις-κλειδιά:
antiinfective agent; lipofundin; nanoparticle; polyhexanide; unclassified drug, adult; antimicrobial activity; antisepsis; article; bacterial growth; disease carrier; hair follicle; human; human tissue; in vivo study; infection prevention; male; nanoemulsion; normal human, Adult; Anti-Infective Agents, Local; Biguanides; Colony Count, Microbial; Disinfection; Double-Blind Method; Drug Carriers; Drug Combinations; Emulsions; Hair Follicle; Humans; Male; Middle Aged; Nanoparticles; Phospholipids; Skin; Sorbitol; Time Factors; Wound Infection; Young Adult
DOI:
10.1016/j.ejpb.2012.11.011
