Τίτλος:
Antimicrobial and cytotoxic isohexenylnaphthazarins from arnebia euchroma (royle) jonst. (boraginaceae) callus and cell suspension culture
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The phytochemical investigation of the n-hexane extract from callus and cell suspension culture of Arnebia euchroma (Royle) Jonst. resulted in the isolation of nine isohexenylnaphthazarins: deoxyalkannin (1), alkannin (2), acetylalkannin (3), isobutyrylalkannin (4), β-hydroxyisovalerylalkannin (5), 2''-(S)-α-methylbutyrylalkannin (6), propionylalkannin (7), teracrylalkannin (8) and acetylshikonin (9). Their structures were determined by MS and NMR spectroscopy. Pigments 2-8 are isolated for the first time from Arnebia in vitro cultures, 4 and 7 are reported in the present work as novel metabolites within the Arnebia genus, while 9 is a known constituent of both natural roots and in vitro cultures of A. euchroma. Moreover, methyl jasmonate and 1-monoglyceryl olate, palmitate and stearate are reported for the first time within the Boraginaceae family. The antimicrobial and cytotoxic activities of all isolated pigment compounds were tested, revealing a very interesting profile. © 2012 by the authors; licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Damianakos, H.
Kretschmer, N.
Syklowska-Baranek, K.
Pietrosiuk, A.
Bauer, R.
Chinou, I.
Περιοδικό:
Molecules (Basel, Switzerland)
Λέξεις-κλειδιά:
antiinfective agent; isohexenylnaphthazarin; naphthoquinone; plant extract, article; bacterium; Boraginaceae; callus; cell proliferation; chemistry; culture technique; drug effect; human; isolation and purification; plant root; tumor cell line, Anti-Infective Agents; Bacteria; Bony Callus; Boraginaceae; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Humans; Naphthoquinones; Plant Extracts; Plant Roots
DOI:
10.3390/molecules171214310
