Τίτλος:
Bi-, Tri-, and polycyclic acylphloroglucinols from hypericum empetrifolium
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The 1H NMR-guided fractionation of a petroleum ether extract of Hypericum empetrifolium led to the isolation of four new bicyclic (1-4), four known bicyclic (5-8), three new tricyclic (9-11), and three new polycyclic acylphloroglucinols (12/13 and 14) possessing a monoterpenoid citran moiety. Compounds 12/13 were isolated as a mixture of two inseparable structural isomers. The compounds showed in vitro antiproliferative activity against human microvascular endothelial cells (HMEC-1) with IC50 values in the range 9.2 ± 2.0 to 29.6 ± 3.5 μM. © 2012 The American Chemical Society and American Society of Pharmacognosy.
Συγγραφείς:
Schmidt, S.
Jürgenliemk, G.
Schmidt, T.J.
Skaltsa, H.
Heilmann, J.
Περιοδικό:
Tropical Journal of Natural Product Research
Λέξεις-κλειδιά:
empetriferdinan a; empetriferdinan b; empetriferdinol; empetrikarinen a; empetrikarinen b; empetrikarinol a; empetrikarinol b; Hypericum empetrifolium extract; plant extract; plant medicinal product; unclassified drug, antiangiogenic activity; article; carbon nuclear magnetic resonance; cell proliferation; chromatography; competitive inhibition; conformation; controlled study; correlation analysis; epoxidation; heteronuclear multiple bond correlation; human; human cell; hydrogen bond; Hypericum empetrifolium; IC 50; in vitro study; isolation procedure; isomer; medicinal plant; microvascular endothelial cell; molecular model; nuclear Overhauser effect; proton nuclear magnetic resonance; proton transport; structure activity relation; ultraviolet spectroscopy, Endothelial Cells; Greece; Humans; Hypericum; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phloroglucinol, Hypericum empetrifolium
