Τίτλος:
Clinical utility of biomarkers in premature atherosclerosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Atherosclerosis is a very complex procedure responsible for the development of coronary artery disease which is the leading cause of death in the civilized world. The obvious pandemic character of atherosclerosis augments the need to discover an ideal biomarker, which will be able to facilitate the clinical diagnosis of the atherosclerosis from the physicians especially in the early stages of the atherosclerotic process. Among the biomarkers that are already used there are classical ones, such as c-reactive protein, interleukins, tumour necrosis factor, apolipoproteins, fibrinogen, homocysteine, and novel promising ones such as lipoprotein-associated phospholipase, asymmetric dimethylarginine, myeloperoxidase, cathepsins and cystatin C. The possibility of combining circulating biomarkers with other methods such as non-invasive and invasive imaging is clinically attractive because this could contribute to the improved diagnosis and understanding of premature atherosclerosis pathogenesis. © 2012 Bentham Science Publishers.
Συγγραφείς:
Kampoli, A.-M.
Tousoulis, D.
Papageorgiou, N.
Pallatza, Z.
Vogiatzi, G.
Briasoulis, A.
Androulakis, E.
Toutouzas, C.
Stougianos, P.
Tentolouris, C.
Stefanadis, C.
Περιοδικό:
Current Medicinal Chemistry
Εκδότης:
Bentham Science Publishers B.V.
Λέξεις-κλειδιά:
1 alkyl 2 acetylglycerophosphocholine esterase; alpha interferon; apolipoprotein B; biological marker; C reactive protein; cathepsin; cystatin C; fibrin; fibrinogen; high density lipoprotein; homocysteine; interleukin 1; interleukin 10; interleukin 18; interleukin 6; intermediate density lipoprotein; low density lipoprotein; myeloperoxidase; n(g),n(g) dimethylarginine; tumor necrosis factor alpha; very low density lipoprotein, article; atherosclerosis; blood vessel parameters; cardiovascular risk; diabetes mellitus; disease course; dyslipidemia; endothelial dysfunction; flow mediated dilation; human; infection; inflammation; intravascular ultrasound; multidetector computed tomography; nonhuman; pathophysiology; positron emission tomography; risk assessment; smoking
DOI:
10.2174/092986712800493039
