Τίτλος:
Dolabellanes with antibacterial activity from the brown alga Dilophus spiralis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Seventeen diterpenes featuring the dolabellane skeleton (1-17) were isolated from the organic extracts of the brown alga Dilophus spiralis. Seven compounds are new natural products (1, 3, 5, 6, 11, 14, 15) and eight are structurally revised (2, 4, 7-10, 12, 13), among which three are reported for the first time from a natural source (4, 9, 10). The structure elucidation and the assignment of the relative configurations of the isolated natural products were based on detailed analyses of their spectroscopic data. The structure of metabolite 10 was confirmed by single-crystal X-ray diffraction analysis, whereas the absolute configurations of compounds 2, 4-10, 12, and 13 were determined using the modified Mosher's method on the semisynthetic product 18 and chemical interconversions. The antibacterial activities of compounds 1-18 were evaluated against six strains of Staphylococcus aureus, including multidrug- and methicillin-resistant variants. © 2010 The American Chemical Society and American Society of Pharmacognosy.
Συγγραφείς:
Ioannou, E.
Quesada, A.
Rahman, M.M.
Gibbons, S.
Vagias, C.
Roussis, V.
Περιοδικό:
Tropical Journal of Natural Product Research
Εκδότης:
American Chemical Society
Λέξεις-κλειδιά:
12 hydroxy 3,7 dolabelladiene; 14 acetoxy 3,4 epoxy 7,18 dolabelladiene; 14 acetoxy 3,7,18 dolabellatriene; 14 hydroxy 3,7,18 dolabellatriene; 14 oxo 3,7,18 dolabellatriene; 2,7,18 dolabellatriene; 3,7,18 dolabellatriene; 7,8 epoxy 14 oxo 3,18 dolabelladiene; algal extract; antibiotic agent; diterpene; dolabellane; natural product; norfloxacin; unclassified drug, antibacterial activity; article; bacterial strain; brown alga; controlled study; Dilophus spiralis; drug isolation; drug structure; methicillin resistant Staphylococcus aureus; nonhuman; spectroscopy; Staphylococcus aureus; X ray diffraction, Dilophus spiralis; Phaeophyceae; Staphylococcus aureus
