Τίτλος:
Relationships of osteoprotegerin with albuminuria and asymmetric dimethylarginine in essential hypertension: Integrating vascular dysfunction
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: To investigate the inter-relationships of osteoprotegerin (OPG) with albumin to creatinine ratio (ACR) and asymmetric dimethylargine (ADMA) in hypertensive patients. Methods: In 198 untreated non-diabetic hypertensive patients [130 males, mean age = 51.5 years, office blood pressure (BP) = 152/98 mmHg] ACR values and OPG and ADMA levels were determined. Results: Based on the median value of OPG distribution (5.03 pmol/l) patients with high (n = 101) compared with those with low OPG values (n = 97) had greater 24-h systolic BP (152 ± 5 versus 137 ± 7 mmHg, p < 0.0001), ACR [25.3 (5 190) versus 17.3 (5 92) mg/g, p = 0.003) and ADMA [0.62 (0.58 0.68) versus 0.57 (0.48 0.62) μmol/l, p = 0.001), independently of confounding factors. Multiple regression analyses revealed that ADMA (b = 0.388, p < 0.0001), 24-h systolic BP (b = 0.228, p = 0.01) and ACR (b = 0.470, p < 0.0001) were independent predictors of OPG (R2 = 0.398, p < 0.0001). Conclusions: In hypertensive patients, high OPG levels are accompanied by pronounced albuminuria and endothelial dysfunction, as reflected by raised ADMA levels. Furthermore, the independent associations of OPG with ACR and ADMA, suggests a link between OPG and the progression of diffuse hypertensive vascular damage. © 2011 Informa UK, Ltd.
Συγγραφείς:
Tsioufis, C.
Aggelis, A.
Dimitriadis, K.
Thomopoulos, C.
Kasiakogias, A.
Tzamou, V.
Kyvelou, S.-M.
Mikhailidis, D.P.
Papademetriou, V.
Stefanadis, C.
Περιοδικό:
Expert Opinion on Therapeutic Targets
Εκδότης:
Informa Healthcare
Λέξεις-κλειδιά:
albumin; creatinine; n(g),n(g) dimethylarginine; osteoprotegerin, adult; albuminuria; article; disease association; endothelial dysfunction; essential hypertension; female; human; major clinical study; male; multiple regression; predictor variable; systolic blood pressure; vascular disease
DOI:
10.1517/14728222.2011.642868
