Τίτλος:
Structure and in vitro antitumor activity evaluation of brominated diterpenes from the red alga Sphaerococcus coronopifolius
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A novel bromoditerpene methyl ketone (1), two new bromoditerpene alcohols featuring a neodolastane (2), and a bromocorodienol skeleton (3), along with 13 previously reported metabolites (4-16) were isolated from the organic extract of Sphaerococcus coronopifolius collected from the rocky coasts of Corfu island in the Ionian Sea. The structures of the new natural products, as well as their relative stereochemistry, were elaborated on the basis of extensive spectral analysis, including 2D NMR experiments. The absolute stereochemistry of metabolite 3 was determined using the modified Mosher's method. The isolated metabolites were evaluated for their antitumoral activity against four human apoptosis-resistant (U373, A549, SKMEL-28, OE21) and two human apoptosis-sensitive (PC-3, LoVo) cancer cell lines with IC50 in vitro growth inhibitory concentrations in the range 3-100 μM. © 2009 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Smyrniotopoulos, V.
Vagias, C.
Bruyère, C.
Lamoral-Theys, D.
Kiss, R.
Roussis, V.
Περιοδικό:
BIOORGANIC AND MEDICINAL CHEMISTRY
Λέξεις-κλειδιά:
antineoplastic agent; brominated diterpene; coronone; diterpene; hydroxy bromocorodienol; natural product; neodolastane; sphaerostanol; unclassified drug, antineoplastic activity; apoptosis; article; cancer cell culture; growth inhibition; human; human cell; IC 50; in vitro study; metabolite; nonhuman; nuclear magnetic resonance; red alga; Sphaerococcus coronopifolius; stereochemistry; structure analysis, Algae, Red; Antineoplastic Agents, Phytogenic; Bromine Compounds; Cell Line, Tumor; Cell Proliferation; Diterpenes; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Neoplasms; Stereoisomerism, Rhodophyta; Sphaerococcus coronopifolius
DOI:
10.1016/j.bmc.2009.12.025
