Περίληψη:
Examination of the digestive and hermaphroditic glands' organic extract of the sea hare Aplysia fasciata yielded 16 metabolites, including eight sesquiterpenes, three diterpenes, and five C15-acetogenins. Among them, three sesquiterpenes, 6-hydroxy-1-brasilene (1), epibrasilenol acetate (2), and 6-epi-β-snyderol (3), one acetogenin, (3Z,9Z)-7-chloro-6-hydroxy- 12-oxo-pentadeca-3,9-dien-1-yne (4), and one diterpene, 16-acetoxy-15-bromo-7- hydroxy-9(11)-parguerene (5), are new natural products. The structure elucidation and the assignment of the relative configurations of the isolated natural products were established on the basis of extensive analyses of their spectroscopic data (NMR, MS, IR). © 2009 American Chemical Society and American Society of Pharmacognosy.
Συγγραφείς:
Ioannou, E.
Nappo, M.
Avila, C.
Vagias, C.
Roussis, V.
Λέξεις-κλειδιά:
acetogenin; diterpene; sesquiterpene derivative, animal experiment; animal tissue; Aplysia fasciata; article; carbon nuclear magnetic resonance; chemical analysis; column chromatography; controlled study; digestive system; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; isolation procedure; marine species; nonhuman; nuclear Overhauser effect; proton nuclear magnetic resonance, Animals; Aplysia; Diterpenes; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oceans and Seas; Sesquiterpenes, Anaspidea; Aplysia fasciata
