Τίτλος:
CMY-31 and CMY-36 cephalosporinases encoded by colEl-like plasmids
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Two CMY-2 derivatives, CMY-31 (Gln 215→Arg) from Salmonella enterica serotype Newport and CMY-36 (Ala 77→Cys and Gln 193→Glu) from Klebsiella pneumoniae, were characterized. Both cephalosporinases functionally resembled CMY-2. bla CMY alleles occurred as parts of a putative transposon comprising ISEcp1B and a Citrobacter freundii-derived sequence carried by ColE1-like plasmids similar to CMY-5-encoding pTKHll from Klebsiella oxytoca. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Συγγραφείς:
Zioga, A.
Whichard, J.M.
Kotsakis, S.D.
Tzouvelekis, L.S.
Tzelepi, E.
Miriagou, V.
Περιοδικό:
Antimicrobial Agents and Chemotherapy
Λέξεις-κλειδιά:
alanine; amoxicillin; amoxicillin plus clavulanic acid; beta lactamase cmy 31; beta lactamase cmy 36; cefepime; cefotaxime; cefoxitin; ceftazidime; ceftriaxone; cefuroxime; cephalosporinase; colicin E1; glutamic acid; glutamine; hydrolase; imipenem; piperacillin; piperacillin plus tazobactam; ticarcillin; unclassified drug, amino acid sequence; amino acid substitution; antibiotic sensitivity; article; bacterial strain; Citrobacter freundii; controlled study; enzyme analysis; enzyme structure; Escherichia coli; gene frequency; Klebsiella oxytoca; Klebsiella pneumoniae; nonhuman; nucleotide sequence; plasmid; priority journal; protein expression; protein function; Salmonella enterica; transposon, Alleles; Amino Acid Sequence; Amino Acid Substitution; Arginine; Base Sequence; beta-Lactamases; Cephalosporinase; Citrobacter freundii; Cysteine; DNA Transposable Elements; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Glutamine; Humans; Hydrolysis; Inhibitory Concentration 50; Isoelectric Point; Kinetics; Klebsiella pneumoniae; Microbial Sensitivity Tests; Models, Genetic; Models, Molecular; Molecular Sequence Data; Plasmids; Salmonella enterica; Sequence Analysis, DNA; Species Specificity; Substrate Specificity; Transformation, Genetic
DOI:
10.1128/AAC.01284-08
