Τίτλος:
Brominated diterpenes with antibacterial activity from the red alga Sphaerococcus coronopifolius
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Four new brominated diterpenes (1, 2, 4, 5), along with two previously reported metabolites (3, 6), were isolated from the organic extract of Sphaerococcus coronopifolius, collected in Palaiokastritsa Bay at the west coast of Corfu Island. The structures of the new products, as well as their relative configuration, were established by means of spectroscopic data analyses, including 2D NMR experiments. The isolated metabolites were evaluated for their antibacterial activity against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) with MICs in the range 0.5-128 μg/mL. © 2008 American Chemical Society and American Society of Pharmacognosy.
Συγγραφείς:
Smyrniotopoulos, V.
Vagias, C.
Rahman, M.M.
Gibbons, S.
Roussis, V.
Περιοδικό:
Tropical Journal of Natural Product Research
Λέξεις-κλειδιά:
bromine; bromo hydroxy 1,2,13,14 tetrahydrosphaerococcenol a; diterpene; hydroperoxy hydroxyisobromosphaerol; hydroxy 1,2 dihydrobromosphaerol; hydroxy 1,2 dihydrosphaerococcenol a; hydroxyisobromosphaerol; norfloxacin; unclassified drug, antibacterial activity; article; controlled study; drug structure; metabolite; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; nonhuman; nuclear magnetic resonance spectroscopy; nuclear Overhauser effect; red alga; Sphaerococcus coronopifolius; structure activity relation, Algae, Red; Anti-Bacterial Agents; Bromine; Diterpenes; Drug Resistance, Multiple; Magnetic Resonance Spectroscopy; Methicillin Resistance; Microbial Sensitivity Tests; Models, Molecular; Staphylococcus aureus, methicillin resistant Staphylococcus aureus; Rhodophyta; Sphaerococcus coronopifolius
