Τίτλος:
Use of statins and risk of haematological malignancies: A meta-analysis of six randomized clinical trials and eight observational studies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: Statins have been suggested to prevent haematological malignancies. Several epidemiological studies have evaluated this association, while randomized controlled trials (RCTs) on cardiovascular outcomes have provided relevant data as secondary end-points. Our aim was to examine the strength of this association through a detailed meta-analysis of the studies published in peer-reviewed literature. Methods: A comprehensive search for articles published up to December 2006 was performed, reviews of each study were conducted and data abstracted. Prior to meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using the random effects model. Results: Fourteen studies (six RCTs, seven case-control and one cohort study) contributed to the analysis. Studies were grouped on the basis of study design, and two separate meta-analyses were conducted. There was no evidence of an association between statin use and haematological malignancies among either RCTs (RR = 0.92, 95% CI 0.72, 1.16) or the observational studies (RR = 0.83, 95% CI 0.53, 1.29). Similarly, we found no evidence of publication bias. However, high heterogeneity was detected among the observational studies. Conclusion: Our meta-analysis findings do not support a potential role of statins in the prevention of haematological malignancies. © 2007 The Authors.
Συγγραφείς:
Bonovas, S.
Filioussi, K.
Tsantes, A.
Sitaras, N.M.
Περιοδικό:
British Journal of Clinical Pharmacology
Λέξεις-κλειδιά:
fluindostatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; mevinolin; placebo; pravastatin; simvastatin, article; case control study; clinical trial; cohort analysis; confidence interval; data analysis; disease association; drug safety; hematologic malignancy; human; meta analysis; methodology; observational study; outcome assessment; priority journal; publishing; randomization; risk factor; systematic review, Epidemiologic Studies; Female; Hematologic Neoplasms; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors; Treatment Outcome
DOI:
10.1111/j.1365-2125.2007.02959.x
