Τίτλος:
Cytotoxic activity of Origanum dictamnus
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Several extracts of Origanum dictamnus, an endemic plant of Greece growing only in the island of Crete and the bioassay-directed isolated ursolic acid, were tested in vitro against the P388 (murine leukemia) and the human bronchial epidermoid cancer NSCLC-N6 (non small cell lung cancer) cell lines. Both the initial dichloromethane extract and the isolated from it ursolic acid exhibited cytotoxic activity. Ursolic acid was also tested in vivo, on murine ascite leukemia P388, where it exhibited at a dose of 50 mg/kg a marginal antileukemic activity. © 2007 Elsevier B.V. All rights reserved.
Συγγραφείς:
Chinou, I.
Liolios, C.
Moreau, D.
Roussakis, C.
Λέξεις-κλειδιά:
dichloromethane; origanum dictamnus extract; plant extract; plant medicinal product; unclassified drug; ursolic acid, animal cell; animal experiment; animal model; antineoplastic activity; article; bioassay; cell line; controlled study; cytotoxicity; Greece; human; human cell; in vitro study; in vivo study; leukemia P 388; lung non small cell cancer; medicinal plant; mouse; murine leukemia; nonhuman; Origanum dictamnus; priority journal, Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Humans; Mice; Mice, Inbred BALB C; Origanum; Phytotherapy; Plant Components, Aerial; Plant Extracts, Murinae; Origanum dictamnus
DOI:
10.1016/j.fitote.2007.02.005
