Τίτλος:
Effect of green tea on angiogenesis and severity of atherosclerosis in cholesterol-fed rabbit
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and Aims: Since the development of the atherosclerotic plaque requires the growth of new microvessels in the plaque itself (vasa vasorum), we postulated that green tea may exert an anti-atherogenic effect. Methods and results: Thirteen male New Zealand white rabbits were studied for 17 weeks. All rabbits were fed an hypecholesterolemic diet. After 2 weeks of adaptation rabbits were randomly assigned into two groups. Animals in Group A were fed the hypercholesterolemic diet and received plain tap water ad libitum. Animals in Group B were fed with the same diet and furthermore received 2.5% (g/g) green tea for 17 weeks. Conclusion: According to our results the atherosclerotic lesions were more severe in Group B than in Group A specimens. Also, the number of VEGF positively stained foam cells and smooth muscle cells of Group B were significantly greater than in Group A. About 30% less plaque was found in Group A than in the control group (Group B). So, our study showed that the consumption of green tea leads to a reduction of atherosclerosis as well as a significant decrease of VEGF expression in the atherosclerotic plaque of rabbit aorta. The hypothesis that probably green tea may produce its anti-atherogenetic effect through an anti-angiogenetic mechanism needs more investigation. © 2006 Elsevier Inc. All rights reserved.
Συγγραφείς:
Kavantzas, N.
Chatziioannou, A.
Yanni, A.E.
Tsakayannis, D.
Balafoutas, D.
Agrogiannis, G.
Perrea, D.
Περιοδικό:
Vascular Pharmacology
Λέξεις-κλειδιά:
green tea extract; vasculotropin, angiogenesis; animal experiment; animal model; antiangiogenic activity; aorta; article; atherosclerotic plaque; cholesterol diet; controlled study; disease severity; drug effect; feeding; hypercholesterolemia; male; nonhuman; priority journal; protein expression; rabbit; smooth muscle fiber; tea; vasa vasorum, Angiogenesis Inhibitors; Animals; Aorta, Abdominal; Aorta, Thoracic; Atherosclerosis; Camellia sinensis; Cholesterol, Dietary; Hypercholesterolemia; Male; Plant Extracts; Plant Leaves; Rabbits; Severity of Illness Index; Vascular Endothelial Growth Factor A
DOI:
10.1016/j.vph.2006.03.008
