Τίτλος:
Fluostatins C-E, novel members of the fluostatin family produced by Streptomyces strain acta 1383
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Three new members of the fluostatin family, fluostatins C-E, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines. © Japan Antibiotics Research Association.
Συγγραφείς:
Baur, S.
Niehaus, J.
Karagouni, A.D.
Katsifas, E.A.
Chalkou, K.
Meintanis, C.
Jones, A.L.
Goodfellow, M.
Ward, A.C.
Beil, W.
Schneider, K.
Süssmuth, R.D.
Fiedler, H.-P.
Περιοδικό:
The Journal of Antibiotics
Λέξεις-κλειδιά:
fluorenone derivative; fluostatin c; fluostatin d; fluostatin e; unclassified drug, article; chromatophore; controlled study; drug activity; drug isolation; drug screening; drug structure; fermentation; high performance liquid chromatography; human; human cell; nonhuman; priority journal; Streptomyces; Streptomyces lavendulae; taxonomy; tumor cell line, Antineoplastic Agents; Cell Line, Tumor; Fluorenes; Humans; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Streptomyces, Streptomyces; Streptomyces lavendulae
