Τίτλος:
Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The root extracts of Onosma leptanhtha were evaluated for their anti-iflammatory and cytotoxic activities. The cyclohexane extract, which appeared as the most active in both assays, has been further subjected to bioassay-directed fractionation to afford the naphthazarine derivatives: β,β-dimethylacrylshikonin (1), isovalerylshikonin (2) and acetylshikonin (3). The evaluation of the anti-inflammatory activity was performed on carrageenan-induced rat paw edema test. All the tested compounds proved to be active, while compound 3 showed the best anti-inflammatory effect. In addition, the cytotoxic activity of the extracts and isolated compounds, was also assayed against L1210 murine lymphoblastic leukemia cell line, and human fibrosarcoma HT-1080 cells. Compound 1 exhibited remarkable cytotoxic activity (390 nM for L1210 cells), which is superior to that of shikonin, which was used as control. © 2005 Elsevier GmbH. All rights reserved.
Συγγραφείς:
Kundakovic, T.
Fokialakis, N.
Dobric, S.
Pratsinis, H.
Kletsas, D.
Kovacevic, N.
Chinou, I.
Εκδότης:
Urban und Fischer Verlag Jena
Λέξεις-κλειδιά:
acetylshikonin; antiinflammatory agent; beta,beta dimethylacrylshikonin; carrageenan; indometacin; isovalerylshikonin; naphthazarine derivative; Onosma leptantha extract; plant extract; shikonin derivative; unclassified drug, animal cell; animal experiment; animal model; antiinflammatory activity; article; bioassay; cell line; controlled study; cytotoxicity; fibrosarcoma; fractionation; herbal medicine; human; human cell; lymphatic leukemia; male; nonhuman; Onosma leptantha; paw edema; plant root; priority journal; rat, Animalia; Murinae; Onosma
DOI:
10.1016/j.phymed.2004.10.009
