Τίτλος:
Aromatic polycationic molecules with restricted conformations: An alternative approach to antiherpes agents
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A series of aromatic polycationic molecules were synthesised and tested as potential non-classical antiherpes agents. Analogue (4) had a high potency in all four of the HSV cell lines used and is far more potent than ribavirin. The fact that none of the new compounds show any selectivity for HSV-2 over HSV-1 may imply that there is no intervention of a HSV-2 glycoprotein C (gC) dependent pathway. © 2005 Bentham Science Publishers Ltd.
Συγγραφείς:
Tsotinis, A.
Vlachou, M.
Eleutheriades, A.
Garratt, P.J.
Ibbett, A.J.
Ng, Y.-F.
Pannecouque, C.
Witvrouw, M.
De Clercq, E.
Περιοδικό:
Letters in Drug Design and Discovery
Λέξεις-κλειδιά:
antivirus agent; aromatic compound; ribavirin, antiviral activity; article; conformation; controlled study; cytotoxicity; drug conformation; drug design; drug potency; drug selectivity; drug synthesis; Herpes simplex virus 1; Herpes simplex virus 2; minimum inhibitory concentration; nonhuman; priority journal; structure activity relation
DOI:
10.2174/1570180054405758
