Τίτλος:
Structurally diverse metal coordination compounds, bearing imidodiphosphinate and diphosphinoamine ligands, as potential inhibitors of the platelet activating factor
Περίληψη:
Metal complexes bearing dichalcogenated imidodiphosphinate [ R2 P (E) NP (E) R2 ] - ligands (E = O, S, Se, Te), which act as (E,E) chelates, exhibit a remarkable variety of three-dimensional structures. A series of such complexes, namely, square-planar [ Cu (OPPh 2)(OPPh 2)N-O,O 2 ], tetrahedral [ Zn (EPPh 2)(EPPh 2)N-E,E 2 ], E = O, S, and octahedral [ Ga (OPPh2)(OPPh 2)N-O,O 3 ], were tested as potential inhibitors of either the platelet activating factor (PAF)- or thrombin-induced aggregation in both washed rabbit platelets and rabbit platelet rich plasma. For comparison, square-planar [ Ni (Ph2 P)2 N-S-CHMePh-P,P X2 ], X = Cl, Br, the corresponding metal salts of all complexes and the (OPPh2)(OPPh2)NH ligand were also investigated. Ga (O,O)3 showed the highest anti-PAF activity but did not inhibit the thrombin-related pathway, whereas Zn (S,S) 2, with also a significant PAF inhibitory effect, exhibited the highest thrombin-related inhibition. Zn (O,O)2 and Cu (O,O)2 inhibited moderately both PAF and thrombin, being more effective towards PAF. This work shows that the PAF-inhibitory action depends on the structure of the complexes studied, with the bulkier Ga (O,O)3 being the most efficient and selective inhibitor. Copyright © 2010 Alexandros B. Tsoupras et al.
Συγγραφείς:
Tsoupras, A.B.
Roulia, M.
Ferentinos, E.
Stamatopoulos, I.
Demopoulos, C.A.
Kyritsis, P.
