Τίτλος:
Synthesis and biological evaluation of novel steroid-modified ether phospholipids
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Platelet activating factor is one of the most potent inflammatory ether phospholipid mediators known and structurally modified analogues are of considerable interest as potential therapeutic preparations. Inspired by the proposed structure for a novel endogenous hydroxy-PAF analogue isolated recently from gingival crevicular fluid, we designed and prepared two novel steroid-modified ether phospholipids. These two novel compounds exhibit marked chemical and biological similarities to their endogenous prototype and they antagonize it being less active in inducing washed platelet aggregation through PAF receptors. © 2005 Elsevier Ireland Ltd. All rights reserved.
Συγγραφείς:
Karantonis, H.C.
Pitsinos, E.N.
Antonopoulou, S.
Couladouros, E.A.
Demopoulos, C.A.
Περιοδικό:
CHEMISTRY AND PHYSICS OF LIPIDS
Λέξεις-κλειδιά:
ether phospholipid; steroid, analytic method; animal cell; article; chemical procedures; chemical reaction; controlled study; drug screening; drug synthesis; nonhuman; priority journal; rabbit; reaction analysis; thrombocyte; thrombocyte aggregation, Acetylation; Animals; Cholestanes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits, Animalia; Oryctolagus cuniculus
DOI:
10.1016/j.chemphyslip.2005.07.007
