Τίτλος:
Nocebo phenomena may be enhanced in aging: Implications for clinical practice
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Nocebo effects, denoting unfavourable outcomes after a medical intervention because of negative expectations rather than a direct pharmacologic action, are an important cause of dropout from clinical trials and non-adherence to medication, and may be especially pertinent for older adults. Several characteristics of aging individuals and their medical care have a potential to augment nocebo susceptibility, such as depression and anxiety, neurodegenerative diseases and chronic pain states, adverse healthcare experiences, generic drug use, age-related stereotypes, and strained patient-physician communication. Nocebo-related research in older adults is hindered by under-representation in clinical trials, medical complexity of geriatric patients, and lack of validated tools to accurately assess susceptibility and efficacy of preventive efforts. © 2020 Elsevier B.V.
Συγγραφείς:
Kravvariti, E.
Kotsani, M.
Mitsikostas, D.D.
Sfikakis, P.P.
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
generic drug, adverse event; aged; aging; Alzheimer disease; anxiety; Article; caregiver; chronic pain; clinical practice; cognitive defect; degenerative disease; depression; doctor patient relationship; drug use; frailty; geriatric patient; human; medical care; multiple chronic conditions; nocebo effect; Parkinson disease; risk factor; social psychology; stereotypy; aging; psychology, Aging; Humans; Nocebo Effect; Risk Factors
DOI:
10.1016/j.maturitas.2020.07.011
