Τίτλος:
Hepatocellular carcinoma drug-eluting bead transarterial chemoembolization (Deb-tace): Outcome analysis using a model based on pre-treatment ct texture features
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
(1) Introduction and Aim: The aim of this study is to investigate the prognostic value, in terms of response and survival, of CT-based radiomics features for patients with HCC undergoing drug-eluting beads transarterial chemoembolization (DEB-TACE). (2) Materials and Methods: Pre-treatment CT examinations of 50 patients with HCC, treated with DEB-TACE were manually segmented to obtain the tumor volumetric region of interest, extracting radiomics features with TexRAD. Response to therapy evaluation was performed basing on post-procedural CT examination compared to pre-procedural CT, using modified RECIST criteria for HCC. The prognostic value of texture analysis was evaluated, investigating the correlation between radiomics features, response to therapy and overall survival. Three models based on texture and clinical variables and a combination of them were finally built; (3) Results: Entropy, skewness, MPP and kurtosis showed a significant correlation with complete response (CR) to TACE (all p < 0.001). A predictive model to identify patients with a high and low probability of CR was evaluated with an ROC curve, with an AUC of 0.733 (p < 0.001). The three models built for survival prediction yielded an HR of 2.19 (95% CI: 2.03–2.35) using texture features, of 1.7 (95% CI: 1.54–1.9) using clinical data and of 4.61 (95% CI: 4.24–5.01) combining both radiomics and clinical data (all p < 0.0001). (4) Conclusion: Texture analysis based on pre-treatment CT examination is associated with response to therapy and survival in patients with HCC undergoing DEB-TACE, especially if combined with clinical data. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Tipaldi, M.A.
Ronconi, E.
Lucertini, E.
Krokidis, M.
Zerunian, M.
Polidori, T.
Begini, P.
Marignani, M.
Mazzuca, F.
Caruso, D.
Rossi, M.
Laghi, A.
Περιοδικό:
DIAGNOSTIC ONCOLOGY
Λέξεις-κλειδιά:
alpha fetoprotein; bilirubin; doxorubicin; microsphere, adult; aged; albumin level; algorithm; area under the curve; Article; ascites; cancer prognosis; chemoembolization; Child Pugh score; clinical article; clinical study; computer assisted tomography; contrast enhancement; drug delivery system; drug eluting bead transarterial chemoembolization; entropy; female; high risk population; human; image segmentation; liver cell carcinoma; liver function; low risk population; male; outcome assessment; overall survival; radiomics; receiver operating characteristic; response evaluation criteria in solid tumors; survival prediction; survival time; treatment response; tumor volume; x-ray computed tomography; Youden index
DOI:
10.3390/diagnostics11060956
