Τίτλος:
Androgen receptor and PIM1 expression in tumor tissue of patients with triple-negative breast cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim: Effective targeted therapies for triple-negative breast cancer (TNBC) are limited. In a subset of TNBC, androgen receptor (AR) plays an important role, while the human proviral integration site for Moloney murine leukemia virus-1 (PIM1) overexpression is also implicated. PIM1 kinases phosphorylate AR, thus regulating its transcriptional activity, regardless of the presence or not of androgens. We evaluated the expression of AR and PIM1 and their prognostic significance in TNBC. Materials and Methods: AR and PIM1 transcripts were quantified by quantitative reverse transcription polymerase chain reaction in formalin-fixed paraffin-embedded tumor from 141 patients with TNBC. Results: AR was expressed in 38.3%, PIM1 in 10.6%, while co-expression of AR and PIM1 was detected in 7/141 cases (5.0%). No prognostic significance of AR or PIM1 was reached for overall or disease-free survival. Conclusion: Co-expression of AR and PIM1 exists in only in a small percentage of patients with TNBC. The implications of this finding in the therapeutic management of patients with TNBC should be investigated in larger patient cohorts. © 2021 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Ntzifa, A.
Strati, A.
Koliou, G.-A.
Zagouri, F.
Pectasides, D.
Pentheroudakis, G.
Christodoulou, C.
Gogas, H.
Magkou, C.
Petraki, C.
Kosmidis, P.
Aravantinos, G.
Kotoula, V.
Fountzilas, G.
Lianidou, E.
Περιοδικό:
Cancer Genomics and Proteomics
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
androgen receptor; aromatase inhibitor; beta 2 microglobulin; estrogen receptor; gonadorelin agonist; progesterone receptor; protein kinase Pim 1; tamoxifen; androgen receptor; PIM1 protein, human; protein kinase Pim 1, adjuvant radiotherapy; adult; aged; Article; cancer adjuvant therapy; cancer hormone therapy; cancer patient; disease free survival; estrogen receptor positive breast cancer; female; gene expression; histology; human; human tissue; immunohistochemistry; major clinical study; overall survival; postmenopause; premenopause; progesterone receptor positive breast cancer; protein expression; protein phosphorylation; real time reverse transcription polymerase chain reaction; transcription regulation; triple negative breast cancer; tumor volume; animal; genetics; metabolism; middle aged; mouse; triple negative breast cancer; very elderly; young adult, Adult; Aged; Aged, 80 and over; Animals; Female; Humans; Mice; Middle Aged; Proto-Oncogene Proteins c-pim-1; Receptors, Androgen; Triple Negative Breast Neoplasms; Young Adult
