Τίτλος:
Dermatofibrosarcoma protuberans of the breast: A case study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Dermatofibrosarcoma protuberans (DFSP) is a superficial mesenchymal neoplasm that originates from the dermal fibroblasts and tends to be locally aggressive. Although infrequent, it is one of the most common cutaneous sarcomas. It mainly affects young and middle-aged patients 20 to 50 years old. Any area of skin may be involved, but the most common sites of presentation are the trunk and extremities. DFSP of the breast is extremely rare. It classically presents as a nodular, exophytic, cutaneous mass, though initially it can manifest as a flat plague and can show persistent but slow growth for many years. Due to increased risk of local recurrence, the standard of care for localized disease is surgical excision with adequate margins. Wide local excision is the most common technique used, but as an alternative Mohs micrographic surgery has emerged as a procedure that offers lower local recurrence rates. Metastases are rare but have been previously reported. In such patients, treatment with imatinib or radiotherapy can be considered. The current case presents a 52-year-old lady with DFSP of the breast that was successfully managed by the Breast Unit of Athens Medical Center-Psychiko Clinic. © 2021, Spandidos Publications. All rights reserved.
Συγγραφείς:
Dimas, D.
Boutas, I.
Potiris, A.
Koufopoulos, N.
Balalis, D.
Sitara, K.
Danglis, F.
Misitzis, I.
Περιοδικό:
Molecular and Clinical Oncology
Εκδότης:
Spandidos Publications
Λέξεις-κλειδιά:
CD34 antigen; Ki 67 antigen, adult; Article; breast lesion; cancer recurrence; cancer surgery; case report; clinical article; dermatofibrosarcoma protuberans; female; fibroblast; health care quality; histology; human; human tissue; immunohistochemistry; mammography; mesenchymoma; metastasis; microcalcification; middle aged; Mohs micrographic surgery; needle biopsy; physical examination; recurrence risk; skin sarcoma; spindle cell carcinoma; subcutaneous tissue
DOI:
10.3892/MCO.2021.2212
