Τίτλος:
Comparative e-cadherin digital expression analysis in HPV and non-HPV related squamous cell carcinoma of the oral cavity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim: Oral squamous cell carcinoma (OSCC) demonstrates aggressive biological behavior in subgroups of patients with specific molecular characteristics. Concerning metastatic potential, disruption of cell to cell adhesion is a critical event in epithelial malignancies including OSCC. Our aim was to investigate the role of E-Cadherin expression in OSCC patients as a valuable protein marker. Materials and Methods: Fifty (n=50) tissue sections derived from primary OSCCs were analyzed by implementing an immunohistochemistry (IHC) assay based on a proper anti-Ecadherin antibody. Digital image analysis was also implemented for an objective evaluation of the corresponding protein expression levels. Results: E-cadherin altered expression (low to negative) was observed in 34/50 (68%) cases, whereas the rest (16/50-32%) demonstrated normal (high to moderate) expression. E-Cadherin abnormal expressionwas associated with the stage of the examined malignancies (p=0.023), whereas no significant correlations with grade, gender, smoking status or human papilloma virus (HPV) history were observed. Conclusion: E-Cadherin down regulation is frequently observed in OSCC and is correlated to a progressively aggressive phenotype of the malignancy in the corresponding patients (advanced stage), but it seems that the impact of HPV persistent infection on these patients is not a critical parameter. © 2021 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
CHRYSOVERGIS, A.
PAPANIKOLAOU, V.
MASTRONIKOLIS, N.
SPYROPOULOU, D.
ADAMOPOULOU, M.
TSIAMBAS, E.
PESCHOS, D.
RAGOS, V.
KYRODIMOS, E.
Περιοδικό:
ANTICANCER RESEARCH
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
uvomorulin; cadherin; tumor marker, Article; cancer patient; cancer staging; clinical feature; controlled study; data analysis software; digital imaging; down regulation; female; histopathology; human; human tissue; image analysis; immunohistochemistry; male; mouth squamous cell carcinoma; papillomavirus infection; priority journal; protein expression level; tissue section; Alphapapillomavirus; cancer grading; complication; disease predisposition; gene expression; genetics; immunohistochemistry; metabolism; mouth tumor; papillomavirus infection; pathology; squamous cell carcinoma; virology, Alphapapillomavirus; Biomarkers, Tumor; Cadherins; Carcinoma, Squamous Cell; Disease Susceptibility; Female; Gene Expression; Humans; Immunohistochemistry; Male; Mouth Neoplasms; Neoplasm Grading; Neoplasm Staging; Papillomavirus Infections
DOI:
10.21873/anticanres.14761
