Τίτλος:
Application of Neutralization and Freeze-Drying Technique for the Preparation of the Beneficial in Drug Delivery 2-Hydroxypropyl-β-Cyclodextrin Complexes with Bioactive Molecules
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Bioavailability of active substances is of great importance for the formulation of a drug product, as it actually reflects drug absorption and achievement of the optimum pharmacological effect. A great number of chemical compounds with excellent pharmacological properties possess low solubility and permeability values, ending in low bioavailability in the human body after administration (especially after per os administration). CDs are oligosaccharides that possess biological properties similar to their linear counterparts, but some of their physicochemical properties differ. They are enhancing bioavailability and solving problems of absorption for poorly soluble lipophilic drugs by forming water-soluble inclusion complexes. For this reason, they are widely used in drug delivery systems (Carrier et al. J Control Release 123:78–99, 2007; Kurkov and Loftsson, Int J Pharm 453:167–80, 2013). The main purpose of this chapter is to show a protocol for the preparation of drug:CDcomplex delivery systems. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς:
Christodoulou, E.
Ntountaniotis, D.
Leonis, G.
Mavromoustakos, T.
Valsami, G.
Περιοδικό:
Methods in Molecular Biology
Εκδότης:
Humana Press Inc.
Λέξεις-κλειδιά:
2 hydroxypropyl beta cyclodextrin; 2 hydroxypropyl beta cyclodextrin; drug, chemical structure; complex formation; dissolution; drug delivery system; freeze drying; in vitro study; solid state; solubility; chemistry; differential scanning calorimetry; drug delivery system; drug formulation; freeze drying; human, 2-Hydroxypropyl-beta-cyclodextrin; Calorimetry, Differential Scanning; Drug Compounding; Drug Delivery Systems; Freeze Drying; Humans; Pharmaceutical Preparations; Solubility
DOI:
10.1007/978-1-0716-0920-0_1
