Τίτλος:
Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery Formulations
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Differential scanning calorimetry (DSC) is a widely utilized method for the interactions of drug molecules with drug delivery systems (DDSs). Herein is described a protocol for studying the interactions and entrapment efficiency of the prototype sartan losartan and the polydynamic, structurally similar irbesartan inside the nontoxic 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD). The thermal scan properties of both sartan molecules have been studied when physically mixed or complexed with the cyclodextrin. The thermograms indeed showed significant differences between the mixtures and complexes, establishing DSC as a valuable method to characterize the state of the drugs in these pharmaceutical formulations. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς:
Naziris, N.
Chountoulesi, M.
Ntountaniotis, D.
Mavromoustakos, T.
Demetzos, C.
Περιοδικό:
Methods in Molecular Biology
Εκδότης:
Humana Press Inc.
Λέξεις-κλειδιά:
2 hydroxypropyl beta cyclodextrin; irbesartan; losartan; cyclodextrin; drug carrier; irbesartan; losartan, complex formation; differential scanning calorimetry; drug delivery system; drug formulation; freeze drying; thermography; chemistry; differential scanning calorimetry, Calorimetry, Differential Scanning; Cyclodextrins; Drug Carriers; Irbesartan; Losartan
DOI:
10.1007/978-1-0716-0920-0_13
