Τίτλος:
Vascular consequences of inflammation: A position statement fromthe eshworking group onvascular structure and function and thearterysociety
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Inflammation is a physiological response to aggression of pathogenic agents aimed at eliminating the aggressor agent and promoting healing. Excessive inflammation, however, may contribute to tissue damage and an alteration of arterial structure and function. Increased arterial stiffness is a well recognized cardiovascular risk factor independent of blood pressure levels and an intermediate endpoint for cardiovascular events. In the present review, we discuss immune-mediated mechanisms by which inflammation can influence arterial physiology and lead to vascular dysfunction such as atherosclerosis and arterial stiffening. We also show that acute inflammation predisposes the vasculature to arterial dysfunction and stiffening, and alteration of endothelial function and that chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease and psoriasis are accompanied by profound arterial dysfunction which is proportional to the severity of inflammation. Current findings suggest that treatment of inflammation by targeted drugs leads to regression of arterial dysfunction. There is hope that these treatments will improve outcomes for patients. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Συγγραφείς:
Zanoli, L.
Briet, M.
Empana, J.P.
Cunha, P.G.
Maki-Petaja, K.M.
Protogerou, A.D.
Tedgui, A.
Touyz, R.M.
Schiffrin, E.L.
Spronck, B.
Bouchard, P.
Vlachopoulos, C.
Bruno, R.M.
Boutouyrie, P.
Περιοδικό:
JOURNAL OF HYPERTENSION
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
adalimumab; antiinflammatory agent; antioxidant; canakinumab; corticosteroid; cyclosporine; etanercept; hydroxymethylglutaryl coenzyme A reductase inhibitor; interleukin 1beta; reactive oxygen metabolite; salicylic acid derivative; tocilizumab; ustekinumab, adaptive immunity; adult; aging; aorta; arterial stiffness; arteriosclerosis; artery disease; Article; atherosclerosis; cardiovascular disease; cardiovascular risk; chronic inflammation; cytokine release; disease severity; human; inflammation; innate immunity; medical society; nonhuman; oxidation reduction state; oxidative stress; priority journal; prophylaxis; psoriasis; rheumatoid arthritis; vasculitis
DOI:
10.1097/HJH.0000000000002508
