Περίληψη:
Background: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. Methods: Associations between prediagnostic plasma levels of 17 primary, secondary, and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations. Results: Positive associations were observed between colon cancer risk and plasma levels of seven conjugated bile acid metabolites: the primary bile acids glycocholic acid (ORquartile 4 vs quartile 1= 2.22, 95% confidence interval [CI] = 1.52 to 3.26), taurocholic acid (OR = 1.78, 95% CI = 1.23 to 2.58), glycochenodeoxycholic acid (OR = 1.68, 95% CI = 1.13 to 2.48), taurochenodeoxycholic acid (OR = 1.62, 95% CI = 1.11 to 2.36), and glycohyocholic acid (OR = 1.65, 95% CI = 1.13 to 2.40), and the secondary bile acids glycodeoxycholic acid (OR = 1.68, 95% CI = 1.12 to 2.54) and taurodeoxycholic acid (OR = 1.54, 95% CI = 1.02 to 2.31). By contrast, unconjugated bile acids and tertiary bile acids were not associated with risk. Conclusions: This prospective study showed that prediagnostic levels of certain conjugated primary and secondary bile acids were positively associated with risk of colon cancer. Our findings support experimental data to suggest that a high bile acid load is colon cancer promotive. © 2020 The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Συγγραφείς:
Kühn, T.
Stepien, M.
López-Nogueroles, M.
Damms-Machado, A.
Sookthai, D.
Johnson, T.
Roca, M.
Hüsing, A.
Maldonado, S.G.
Cross, A.J.
Murphy, N.
Freisling, H.
Rinaldi, S.
Scalbert, A.
Fedirko, V.
Severi, G.
Boutron-Ruault, M.-C.
Mancini, F.R.
Sowah, S.A.
Boeing, H.
Jakszyn, P.
Sánchez, M.J.
Merino, S.
Colorado-Yohar, S.
Barricarte, A.
Khaw, K.T.
Schmidt, J.A.
Perez-Cornago, A.
Trichopoulou, A.
Karakatsani, A.
Thriskos, P.
Palli, D.
Agnoli, C.
Tumino, R.
Sacerdote, C.
Panico, S.
Bueno-De-Mesquita, B.
Van Gils, C.H.
Heath, A.K.
Gunter, M.J.
Riboli, E.
Lahoz, A.
Jenab, M.
Kaaks, R.
Λέξεις-κλειδιά:
bile acid; bile acid conjugate; chenodeoxycholic acid; cholic acid; deoxycholic acid; glycochenodeoxycholic acid; glycocholic acid; glycodeoxycholic acid; glycohyocholic acid; glycolithocholic acid; glycoursodeoxycholic acid; hyocholic acid; tauro alpha muricholic acid; taurochenodeoxycholic acid; taurocholic acid; taurodeoxycholic acid; taurohyocholic acid; tauroursodeoxycholic acid; unclassified drug; ursodeoxycholic acid; bile acid, adult; aged; Article; bile acid blood level; bile acid metabolism; cancer incidence; cancer registry; cancer risk; case control study; cohort analysis; colon cancer; comparative study; controlled clinical trial; controlled study; female; follow up; heredity; human; limit of detection; major clinical study; male; multicenter study; priority journal; prospective study; tandem mass spectrometry; blood; clinical trial; colon tumor; middle aged; risk; Spain, Adult; Aged; Bile Acids and Salts; Case-Control Studies; Cohort Studies; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Risk; Spain
