Περίληψη:
Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness. © 2019 International Agency for Research on Cancer (IARC/WHO); licensed by UICC
Συγγραφείς:
Kliemann, N.
Murphy, N.
Viallon, V.
Freisling, H.
Tsilidis, K.K.
Rinaldi, S.
Mancini, F.R.
Fagherazzi, G.
Boutron-Ruault, M.-C.
Boeing, H.
Schulze, M.B.
Masala, G.
Krogh, V.
Sacerdote, C.
de Magistris, M.S.
Bueno-de-Mesquita, B.
Weiderpass, E.
Kühn, T.
Kaaks, R.
Jakszyn, P.
Redondo-Sánchez, D.
Amiano, P.
Chirlaque, M.-D.
Gurrea, A.B.
Ericson, U.
Drake, I.
Nøst, T.H.
Aune, D.
May, A.M.
Tjønneland, A.
Dahm, C.C.
Overvad, K.
Tumino, R.
Quirós, J.R.
Trichopoulou, A.
Karakatsani, A.
La Vecchia, C.
Nilsson, L.M.
Riboli, E.
Huybrechts, I.
Gunter, M.J.
Λέξεις-κλειδιά:
adult; Article; basal metabolic rate; body mass; breast cancer; cancer risk; colon cancer; endometrium cancer; esophageal adenocarcinoma; female; human; male; obesity; pancreas cancer; postmenopause; priority journal; thyroid cancer; aged; basal metabolic rate; classification; clinical trial; complication; Europe; incidence; metabolism; middle aged; multicenter study; neoplasm; nutritional assessment; prospective study; sexual characteristics, Adult; Aged; Basal Metabolism; Europe; Female; Humans; Incidence; Male; Middle Aged; Neoplasms; Nutrition Assessment; Obesity; Prospective Studies; Sex Characteristics
