Τίτλος:
What is considered cardiotoxicity of anthracyclines in animal studies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Anthracyclines are commonly used anticancer drugs with well.known and extensively studied cardiotoxic effects in humans. In the clinical setting guidelines for assessing cardiotoxicity are well.established with important therapeutic implications. Cardiotoxicity in terms of impairment of cardiac function is largely diagnosed by echocardiography and based on objective metrics of cardiac function. Until this day, cardiotoxicity is not an endpoint in the current general toxicology and safety pharmacology preclinical studies, although other classes of drugs apart from anthracyclines, along with everyday chemicals have been shown to manifest cardiotoxic properties. Also, in the relevant literature there are not well.established objective criteria or reference values in order to uniformly characterize cardiotoxic adverse effects in animal models. This in depth review focuses on the evaluation of two important echocardiographic indices, namely ejection fraction and fractional shortening, in the literature concerning anthracycline administration to rats as the reference laboratory animal model. The analysis of the gathered data gives promising results and solid prospects for both, defining anthracycline cardiotoxicity objective values and delineating the guidelines for assessing cardiotoxicity as a separate hazard class in animal preclinical studies for regulatory purposes. © 2020 Spandidos Publications. All rights reserved.
Συγγραφείς:
Georgiadis, N.
Tsarouhas, K.
Rezaee, R.
Nepka, H.
Kass, G.E.N.
Dorne, J.-L.C.M.
Stagkos, D.
Toutouzas, K.
Spandidos, D.A.
Kouretas, D.
Tsitsimpikou, C.
Περιοδικό:
ONCOLOGY REPORTS
Εκδότης:
Spandidos Publications
Λέξεις-κλειδιά:
anthracycline; daunorubicin; doxorubicin; epirubicin; anthracycline; antineoplastic antibiotic, age; alcohol consumption; Article; cardiotoxicity; cardiovascular risk; congestive heart failure; disease association; drug safety; echocardiography; fractional shortening; heart left ventricle contractility; heart left ventricle ejection fraction; heart left ventricle enddiastolic diameter; heart left ventricle enddiastolic volume; heart left ventricle endsystolic diameter; heart left ventricle endsystolic volume; heart muscle contractility; hypercholesterolemia; hypertension; image analysis; nonhuman; obesity; physical inactivity; priority journal; tobacco use; animal; animal model; cardiotoxicity; practice guideline; procedures; rat; toxicity testing, Animals; Anthracyclines; Antibiotics, Antineoplastic; Cardiotoxicity; Echocardiography; Guidelines as Topic; Models, Animal; Rats; Toxicity Tests
DOI:
10.3892/or.2020.7688
