Τίτλος:
Visceral adiposity index outperforms common anthropometric indices in predicting 10-year diabetes risk: Results from the ATTICA study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common anthropometric indices. Methods: In 2001 to 2002, the ATTICA study (Greece) recruited a random sample of 1514 and 1528 CVD-free men (18-87 years old) and women (18-89 years old), respectively. Sociodemographic, lifestyle, clinical, and biochemical characteristics of participants were measured at baseline, and the 10-year follow-up was performed during 2011 to 2012. After excluding participants with diabetes at baseline and participants without complete follow-up information regarding diabetes status and/or baseline VAI values, the working sample consisted of 1049 participants. In this sample, the predictive value of baseline VAI value was studied in relation to 10-year diabetes incidence. Results: One hundred thirty-three incident cases of diabetes were documented (10-year incidence: 12.7%). In the fully adjusted model, VAI significantly increased diabetes risk by 22% (OR per 1-unit increase =1.22; 95%CI, 1.09-1.37). Markers of oxidative stress and inflammation were found to, at least partly, mediate this relationship. Also, a moderating effect of menstruation status was revealed among women. VAI showed the highest predictive ability and contributed the most, along with waist-to-height ratio, to the correct classification of participants who developed diabetes. Conclusions: The present findings suggest that VAI may be a useful index for predicting long-term diabetes development and may exhibit better predictive ability to commonly used anthropometric indices. © 2019 John Wiley & Sons, Ltd.
Συγγραφείς:
Koloverou, E.
Panagiotakos, D.B.
Kyrou, I.
Stefanadis, C.
Chrysohoou, C.
Georgousopoulou, E.N.
Skoumas, I.
Tousoulis, D.
Pitsavos, C.
the ATTICA Study group
Περιοδικό:
Diabetes/Metabolism Research and Reviews
Εκδότης:
John Wiley and Sons Ltd
Λέξεις-κλειδιά:
adult; aged; anthropometric parameters; Article; cohort analysis; disease marker; female; human; incidence; inflammation; intra-abdominal fat; major clinical study; male; menstruation; non insulin dependent diabetes mellitus; obesity; oxidative stress; predictive value; priority journal; risk assessment; visceral adiposity index; waist to height ratio; abdominal obesity; adolescent; anthropometry; body mass; complication; follow up; Greece; intra-abdominal fat; middle aged; non insulin dependent diabetes mellitus; pathology; prospective study; risk factor; very elderly; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Anthropometry; Body Mass Index; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Greece; Humans; Incidence; Intra-Abdominal Fat; Male; Middle Aged; Obesity, Abdominal; Predictive Value of Tests; Prospective Studies; Risk Factors; Young Adult
