Τίτλος:
Central diabetes insipidus and pituitary stalk thickening in adults: Distinction of neoplastic from non-neoplastic lesions
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Context: Association of central diabetes insipidus (CDI) and pituitary stalk thickening (PST) may have several etiologies (including malignancies) and differential diagnosis remains often difficult. Objective: The purpose of this study was to identify which clinical, biochemical or radiological features could help clinicians to make an etiological diagnosis, especially distinguishing neoplastic from non-neoplastic pituitary stalk lesions. Design and methods: We retrospectively analyzed clinical, biochemical, radiological and histological data of 38 adult patients diagnosed with CDI and PST of proven etiology. Results: Of the 38 pituitary stalk lesions included, 11 (29%) were neoplastic. A histopathological diagnosis was obtained in 22/38 (58%) patients. The three most frequently observed etiologies of PST were neuroinfundibulitis (34%), germinoma (21%) and histiocytosis (18%). Pituitary stalk thickness was larger for neoplastic lesions, particularly germinomas. Male gender and a very young age were statistically associated with a risk of germinoma. At least one anterior pituitary deficit was observed in nearly 60% of patients. Patients with neoplastic PST were more affected by multiple anterior pituitary dysfunction than patients with benign PST. A high serum prolactin level was individually the best predictor of a neoplastic origin (90% sensitivity and 60% specificity for a serum prolactin level 1.27-fold above the normal upper limit (ULN)). Conclusion: We confirm a relatively high risk of malignancy in adult patients presenting with the association of CDI and PST. Young age, male gender, a very large thickening of the stalk, multiple anterior pituitary deficits and prolactin above 1.3× ULN increase the likelihood of a neoplastic origin. © 2020 European Society of Endocrinology Printed in Great Britain.
Συγγραφείς:
Devuyst, F.
Kazakou, P.
Balériaux, D.
Alexopoulou, O.
Burniat, A.
Salenave, S.
Chanson, P.
Corvilain, B.
Maiter, D.
Περιοδικό:
European Journal of Endocrinology
Εκδότης:
BioScientifica Ltd
Λέξεις-κλειδιά:
adult; Article; biochemical analysis; cancer classification; clinical article; clinical feature; diabetes insipidus; female; follow up; germ cell tumor; histiocytosis; histopathology; human; human tissue; hypophysis tumor; male; neurologic disease; pituitary stalk; predictive value; priority journal; prolactin blood level; radiological parameters; retrospective study; sensitivity and specificity
